Evaluation of Clinical and Radiographic Parameters in Bony Defects Treated With Recombinant Human Platelet-derived Growth Factor in Combination With Allograft

SPSI-010613

Growth factors are defined as small proteins that trigger a cellular response after binding to cell receptors; Tissue engineering is now clinically applicable in a commercially available system involving the use of recombinant human platelet-derived growth factor. The objective of this study is to evaluate clinical and radiographic parameters in bone defects treated with platelet-derived growth factor in combination with allograft. Our hypothesis: Defects treated with DFDBA and rhPDGF-BB have better clinically and radiographic results that the defects treated with DFDBA and saline solution.

2024-01-10

2024-07-16

2025-01-15

Recruiting

Early phase I

30

Inclusion Criteria: * Clinical diagnosis of periodontitis * Infrabony defects of 2 walls, 3 walls and combined defects * Patients ASA (American Society of Anesthesiologists) I and II * Patients who smoke less than 10 cigarettes Exclusion Criteria: * Patients undergoing bisphosphonate therapy * Furcation defects * Patients with evidence of blood dyscrasias. * Pregnant patient

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2024-05-01