Clinical trial
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Crossover Trial to Evaluate the Efficacy and Tolerability of Rizatriptan 10 mg for the Treatment of Acute Migraine in Sumatriptan Non-Responders
Name
0462-087
Description
A study to provide evidence supporting the benefit of Rizatriptan in patients who have an inadequate response to sumatriptan.
Trial arms
Trial start
2009-06-10
Estimated PCD
2010-01-12
Trial end
2010-01-12
Status
Completed
Phase
Early phase I
Treatment
rizatriptan
Single dose of 10 mg orally disintegrating tablet at onset of migraine attack
Arms:
Treatment Sequence A, Treatment Sequence B, Treatment Sequence C
Comparator: Placebo
Placebo to Rizatriptan
Arms:
Treatment Sequence A, Treatment Sequence B, Treatment Sequence C
Comparator: Sumatriptan
single dose of generic sumatriptan 100 mg at onset of migraine attack
Arms:
Baseline Phase
Size
109
Primary endpoint
Pain Relief (PR)
2 hours post dose
Eligibility criteria
Inclusion Criteria:
* Patient has a history of migraine with or without aura for 1 year or more with 2-8 moderate or severe migraine attacks per month
* Patient generally does not respond to treatment with sumatriptan
* Patient of reproductive potential agrees to remain abstinent or use one method of highly effective birth control (i.e. IUD, condoms, hormonal contraceptive, diaphragm, vasectomy) for the duration of the study
* Patient is able to complete paper diary
Exclusion Criteria:
* Patient is pregnant or breast feeding or excepts to become pregnant during the study
* Patient has history of mild migraine attacks or migraines that usually resolve spontaneously in less than 2 hours
* Patient has basilar or hemiplegic migraines
* Patient is unable to distinguish between migraine attacks from other types of headaches
* Patient has more than 15 headache-days per month
* Patient was greater than 50 years old at age of migraine onset
* Patient has failed to respond to 3 or more triptans
* Patient has a repeated history of failing to respond to or tolerate rizatriptan
* Patient uses opioids as primary migraine therapy
* Patient uses daily opioids
* Patient has a history of Cerebrovascular Accident (CVA) or other significant cardiovascular disease
* Patient has uncontrolled hypertension
* Patient has a history of neoplastic disease
* Patient is taking a serotonin reuptake inhibitor (SSRI or SNRI) where the dose has changed 3 months prior to screening
* Patient has a history of drug or alcohol abuse
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'CROSSOVER', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 109, 'type': 'ACTUAL'}}
Updated at
2024-05-10
1 organization
3 products
1 indication
Organization
Organon and CoProduct
rizatriptanIndication
MigraineProduct
ComparatorProduct
Sumatriptan