Evaluation of Changes in Corneal Stromal Thickness Using Anterior Segment OCT Following Treatment of Neurotrophic Ulcers With Oxervate

IIR-2019-1139

Neurotrophic keratitis (NK) is a condition where the cornea, or clear outer covering of the eye, has reduced sensation due to a variety of reasons. In more advanced cases of NK, the cornea can develop an area of thinning called an ulcer. The purpose of this research is to find out if Oxervate (cenegermin-bkbj 0.002%) an FDA-approved treatment for neurotrophic corneal ulcers leads to an increase in thickness of the corneal stroma (middle layer of the cornea) during and after treatment of a neurotrophic ulcer. Corneal thickness will be measured using optical coherence tomography (OCT), a non-contact imaging device used routinely in ophthalmology examinations. Corneal sensation will also be measured during and after treatment with a device called a Cochet-Bonnet esthesiometer to see if the treatment increases corneal sensation.

2020-10-01

2024-06-30

2024-12-31

Recruiting

10

Inclusion Criteria: * Neurotrophic keratitis with stage 3 neurotrophic ulcer (stromal thinning) * Decreased corneal sensation relative to fellow eye determined qualitatively using wisp of cotton-tipped applicator to compare sensation in each eye without anesthesia. Exclusion Criteria: * Impending corneal perforation (descemetocele) * Unable to physically complete diagnostic testing (cannot position head into slit lamp or OCT) * Unable to commit to 6 month follow up prior to initiating study * Unable to self-administer study drug following explanation and demonstration by PI and study coordinator * Active infectious infiltrate clinically worsening by history or clinical appearance * Pregnancy; patients must agree to use an acceptable form of birth control during study participation.

{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'PROSPECTIVE'}, 'enrollmentInfo': {'count': 10, 'type': 'ESTIMATED'}}

2024-04-17