The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial

UTEM ELKI

Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.

2023-10-01

2024-05-30

2024-06-30

Recruiting

50

INCLUSION CRITERIA: * Patients aged 18 or older. * American society of anesthesiologists' (ASA) physical status of I-III. * Elective open colorectal surgery. NON INCLUSION CRITERIA: * Patients with contraindications to lidocaine or ketamine. * Corticosteroid therapy within the last 6 months. * History of immunosuppressive therapy. * History of surgery in the last 3 months. * Personal medical history of inflammatory bowel disease. * Personal medical history of cardiac arrythmias or conduction disorders. * Alcohol or drug abuse. * Chronic use of opioids or benzodiazepines. EXCLUSION CRITERIA: * Severe intraoperative complications. * Duration of surgery longer than 5 hours.

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Intravenous Lidocaine vs intravenous ketamine', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER']}}, 'enrollmentInfo': {'count': 50, 'type': 'ESTIMATED'}}

2024-04-16