Clinical trial
Open-labeled, Randomized, Controlled Phase IV Clinical Trial to Evaluate the Immunogenicity and Safety of Booster Dose of sIPV Co-administered With MMR and HepA-I.
Name
PRO-sIPV-4003
Description
This is an Open-labeled, Randomized, Controlled Phase IV Clinical Trial to Evaluate the Immunogenicity and Safety of Booster Dose of Sabin Strain Inactivated Poliovirus Vaccine (Vero cell) (sIPV) Co-administered with Measles, Mumps, Rubella (MMR) Combined Live Attenuated Vaccine and Inactivated Hepatitis A (Hep-A) Vaccine.
Trial arms
Trial start
2024-07-10
Estimated PCD
2025-02-10
Trial end
2025-03-10
Status
Not yet recruiting
Phase
Early phase I
Treatment
sIPV
vaccination with sIPV
Arms:
Control group 1, Trial group 1, Trial group 2
MMR
vaccination with MMR
Arms:
Control group 2, Trial group 1
HepA-I
vaccination with HepA-I
Arms:
Control group 3, Trial group 2
Size
960
Primary endpoint
seroconversion rates (SCRs) of sIPV neutralizing antibody against different poliovirus serotypes (Type I, II and III)
30 days
SCRs of anti-meascles IgG antibodies
30 days
SCRs of anti-mumps IgG antibodies
30 days
SCRs of anti-rubella IgG antibodies
30 days
SCRs of anti-hepatitis A IgG antibodies
30 days
Eligibility criteria
Inclusion Criteria:
* (1) healthy toddlers aged 18 months (+4 months);
* (2) completed three doses of sIPV primary immunization;
* (3) completed one dose of MMR vaccination;
* (4) able to provide proof of vaccination;
* (5) able to provide legal proof of identity;
* (6) The guardians of the participants were able to understand and agree to sign the informed consent.
Exclusion Criteria:
* (1) a history of vaccination with a polio-containing vaccine component in addition to three sIPV primary doses, according to the vaccination certificate;
* (2) have received a second dose of MMR vaccine or a vaccine containing a vaccine for measles, mumps or rubella, or hepatitis A vaccine (inactivated or attenuated), according to the vaccination certificate;
* (3) previous history of polio or measles or mumps or rubella or hepatitis A;
* (4) known severe allergy to the vaccine or vaccine components, such as urticaria, dyspnea, angioedema;
* (5) severe congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc.;
* (6) with autoimmune diseases or immunodeficiency diseases (including but not limited to systemic lupus erythematosus, asplenia, functional asplenia, and HIV infection);
* (7) abnormal coagulation function (such as coagulation factor deficiency, platelet abnormality), or obvious bleeding, hematoma, or ecchymosis after previous intramuscular injection or venipuncture;
* (8) have/have had a serious neurological disease (e.g., encephalopathy, epilepsy, convulsions \[other than febrile convulsions\]) or psychosis, a family history of neurological disease or psychosis;
* (9) receiving immunosuppressive or other immunomodulatory therapy, cytotoxic therapy within the past 6 months, or planning to receive such treatment during the trial;
* (10) have received an immune globulin or other blood products within the past 6 months or plan to receive such treatment during the trial;
* (11) receipt of other investigational vaccines within 30 days before vaccination with the investigational vaccines;
* (12) receipt of live attenuated vaccine within 28 days before vaccination with the investigational vaccine;
* (13) receipt of subunit or inactivated vaccine within 7 days before vaccination with the investigational vaccine;
* (14) acute diseases or acute episodes of chronic diseases within the past 7 days;
* (15) Axillary temperature \>37.0℃ if fever occurred before vaccination;
* (16) which are unsuitable for participation in the clinical trial as judged by the investigators.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Randomized Controlled Trial (RCT)', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 960, 'type': 'ESTIMATED'}}
Updated at
2024-06-04
1 organization
3 products
1 indication
Organization
Sinovac BiotechProduct
sIPVIndication
PoliomyelitisProduct
MMRProduct
HepA-I