Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina Pectoris - METHANE Study

METHANE

The purpose of this study is to evaluate differences in the pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite in patients who received ticagrelor followed with methoxyflurane versus ticagrelor followed with morphine or ticagrelor alone due to unstable angina pectoris

2020-06-01

2024-01-31

2024-02-29

Completed

Early phase I

72

Inclusion Criteria: * Provision of informed consent prior to any study specific procedures * Diagnosis of unstable angina * Male or non-pregnant female, aged 18-80 years * Provision of informed consent for angiography and PCI * GRACE score \<140 pts Exclusion Criteria: * Treatment with ticlopidine, clopidogrel, prasugrel or ticagrelor within 14 days before the study enrollment * Current treatment with morphine or any opioid "mi" receptor agonist * Hypersensitivity to ticagrelor * Current treatment with oral anticoagulant or chronic therapy with low-molecular-weight heparin * Active bleeding * History of intracranial hemorrhage * Recent gastrointestinal bleeding (within 30 days) * History of coagulation disorders * Platelet count less than \<100 x10\^3/mcl * Hemoglobin concentration less than 10.0 g/dl * History of moderate or severe hepatic impairment * History of major surgery or severe trauma (within 3 months) * Risk of bradycardic events as judged by the investigator * Second- or third-degree atrioventricular block during screening for eligibility * History of asthma or severe chronic obstructive pulmonary disease * Kidney disease requiring dialysis * Manifest infection or inflammatory state * Killip class III or IV during screening for eligibility * Respiratory failure * History of severe chronic heart failure (NYHA class III or IV) * Concomitant therapy with strong CYP3A inhibitors (ketoconazole, itraconazole, voriconazole, telithromycin, clarithromycin, nefazadone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir) or strong CYP3A inducers (rifampicin, phenytoin, carbamazepine, dexamethasone, phenobarbital) within 14 days and during study treatment * Body weight below 50 kg

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 72, 'type': 'ACTUAL'}}

2024-03-12