Clinical trial
A Phase 2, Randomized, Double-blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Investigational Tirzepatide Doses in Participants With Type 2 Diabetes and Obesity
Name
18739
Description
The main purpose of this study is to learn more about the safety and efficacy of investigational tirzepatide doses in participants with Type 2 diabetes and obesity that are already taking metformin. The study will last for about 89 weeks.
Trial arms
Trial start
2023-09-21
Estimated PCD
2024-12-24
Trial end
2025-09-30
Status
Recruiting
Phase
Early phase I
Treatment
Tirzepatide
Administered SC
Arms:
Tirzepatide, Tirzepatide High Dose 1, Tirzepatide High Dose 2
Other names:
LY3298176
Placebo
Administered SC
Arms:
Placebo
Size
350
Primary endpoint
Percent Change From Baseline in Body Weight
Baseline (Week 0), Week 44
Eligibility criteria
Inclusion Criteria
* Have a Body Mass Index (BMI) ≥35 kilogram/square meter (kg/m²) at screening.
* Have had stable body weight (±5%) during the 90 days preceding screening.
* Have been diagnosed with Type 2 Diabetes (T2D).
* Have been on a stable treatment of metformin only at least 90 days preceding screening and between screening and randomization with the minimum effective dose of ≥1500 milligram (mg)/day.
Exclusion Criteria:
* Have Type 1 Diabetes (T1D), history of ketoacidosis or hyperosmolar state/coma, or any other types of diabetes except T2D.
* Have had 1 or more episode of severe hypoglycemia and/or 1 or more episode of hypoglycemia unawareness within 6 months prior to screening.
* Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema.
* Have a prior or planned surgical treatment for obesity.
* Use products intended for weight loss including prescription drugs, over the counter (OTC) drugs, and herbal preparations, within 3 months prior to screening.
* Have renal impairment measured as estimated glomerular filtration rate (eGFR) \<45 milliliter/min (mL/min)/1.73 m².
* Have any of the following cardiovascular (CV) conditions within 2 months prior to screening.
* acute myocardial infarction.
* cerebrovascular accident (stroke).
* unstable angina .
* hospitalization due to congestive heart failure, or
* coronary artery revascularization.
* Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia (MEN) syndrome Type 2.
* Have a history of chronic or acute pancreatitis.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 350, 'type': 'ESTIMATED'}}
Updated at
2024-05-29
1 organization
1 product
1 drug
2 indications
Organization
Eli Lilly and CompanyProduct
TirzepatideIndication
Type 2 DiabetesIndication
ObesityDrug
Varlilumab