Clinical trial

A Comparative Study Between Articaine Alone Versus Articaine Plus Dexmedetomidine for Ambulatory Orthopedic Surgery Under Supraclavicular Block

Name
RC 19-1-2024
Description
Articaine has emerged as a local anesthetic (LA) that produces sensory and motor blockade shorter than bupivacaine and lower in neurotoxicity than lidocaine. Studies have shown that adding dexmedetomidine to LA produces prolongation of sensory and motor bock duration. Early regain of motor power with adequate analgesia is needed in ambulatory surgery, for early start of physiotherapy. This study was designed to test efficacy of adding dexmedetomidine to articaine on the duration of sensory and motor block.
Trial arms
Trial start
2024-02-01
Estimated PCD
2024-08-01
Trial end
2024-08-20
Status
Recruiting
Treatment
Articaine
supraclavicular brachial plexus block with articaine 2%
Arms:
Articaine alone, Articaine and Dexmedetomidine
Dexmedetomidine
supraclavicular brachial plexus block with articaine 2% in addition with Dexmedetomidine
Arms:
Articaine and Dexmedetomidine
Size
66
Primary endpoint
Sensory block duration
24 hours post block
Eligibility criteria
Inclusion Criteria: * aged 18-60 years planned for upper limb surgery below the midhumerus with an expected time of less than 90 min usually under tourniquet. Exclusion Criteria: * allergies to local anesthetic, * those with ASA III and IV, * patients who refuse to participate, * uncooperative patients, * patients who have infection at the site of injection, * patients who have bleeding disorder, and patients on anticoagulant drugs.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 66, 'type': 'ESTIMATED'}}
Updated at
2024-05-23

1 organization

2 products

2 indications

Organization
Benha University
Product
Articaine
Indication
Acute