The Efficacy and Safety of Anti-PD-1 Combined With Thymosin and SOX in Neoadjuvant Treatment of cStage IIII Gastric or Esophagogastric Junctional Adenocarcinoma: A Prospective, Open-label, Single-arm, Phase II Clinical Study

NAPTSOX24

This Phase II clinical study is a prospective, open-label, single-arm trial designed to evaluate the efficacy and safety of combining anti-PD-1 therapy (sintilimab) with thymosin α1 and the SOX chemotherapy regimen as a neoadjuvant treatment for patients with clinical stage III gastric or esophagogastric junction (GEJ) adenocarcinoma. The primary objective is to explore the therapeutic efficacy and safety of this combined treatment approach. The secondary objective is to assess its impact on the tumor immune microenvironment in locally advanced gastric cancer. Study Design The study plans to enroll 30 patients who have been pathologically confirmed as HER2-negative and diagnosed with resectable stage III gastric or GEJ adenocarcinoma (Siewert type III and type II without the need for thoracotomy). The study includes multiple steps: Treatment Regimen: Participants will receive three cycles of sintilimab combined with the SOX regimen (oxaliplatin and S-1) and nine weeks of thymosin α1 before surgery. Assessment Points: Tumor response will be evaluated through imaging studies at the end of the second and third cycles of neoadjuvant therapy. Post-treatment surgery is scheduled within 2-6 weeks following the last dose of the third cycle. Pathological Evaluation: Surgical tumor samples will undergo pathological examination, including assessments for pathological complete response (pCR), tumor regression grade (TRG), major pathological response (MPR), overall response rate (ORR), disease control rate (DCR), clinical downstaging rate, and R0 resection rate. Safety Monitoring: Adverse events will be monitored throughout the treatment period to evaluate the safety of the neoadjuvant immunochemotherapy regimen. Follow-up: Patients will be followed up to calculate disease-free survival (DFS) and overall survival (OS). Eligibility Criteria Inclusion Criteria: i, Confirmed diagnosis of HER2-negative gastric or GEJ adenocarcinoma. ii. Clinical stage III, resectable tumors. iii. Adequate organ function and performance status. Exclusion Criteria: i. Prior treatment with immune checkpoint inhibitors. ii. History of autoimmune diseases or other malignancies. iii. Severe comorbidities that could interfere with the study. Goals and Objectives Primary Goal: To determine the effectiveness and safety of combining sintilimab with thymosin α1 and SOX as a neoadjuvant therapy. Secondary Goal: To investigate changes in the tumor immune microenvironment induced by the treatment and their correlation with therapeutic efficacy. Study Implications This study aims to provide critical insights into the potential benefits of integrating immunotherapy with chemotherapy and thymosin α1 in treating locally advanced gastric cancer. By focusing on both efficacy and immune microenvironment alterations, the findings could pave the way for novel neoadjuvant treatment strategies and improve clinical outcomes for gastric cancer patients.

2024-06-01

2027-06-01

2027-12-01

Not yet recruiting

Early phase I

30

Inclusion Criteria: * Age and Diagnosis: Patients aged 18-75 years with gastric (G) or gastroesophageal junction (GEJ) adenocarcinoma, regardless of gender. * Stage and Diagnosis Confirmation: According to the 8th edition of AJCC staging for gastric cancer, patients must be assessed via abdominal CT as cStage III (cT3-4aN1-3M0). Diagnosis must be confirmed by endoscopy and pathology as G/GEJ adenocarcinoma (HER-2 negative). Only patients with Siewert type III and type II (who do not require combined thoracic surgery) GEJ cancer are eligible. * Surgical Assessment: Tumors must be deemed resectable with curative intent (R0 resection) as determined by a gastrointestinal surgeon and a radiologist. Patients must agree to undergo radical surgery and be deemed operable by a surgeon. * Previous Treatments: Patients must not have received prior systemic treatment for the current disease, including surgery, anti-tumor chemotherapy, radiotherapy, or immunotherapy. * Survival Expectancy: Expected survival of at least 3 months. * Measurable Disease: Tumors must be measurable according to RECIST v1.1 criteria. * Performance Status: ECOG PS score of 0-1 within 7 days prior to the first dose. * Cardiac Function: Good cardiac function, suitable for curative surgery. Preoperative evaluation by a cardiologist is required if there are clinical indications of underlying ischemic, valvular, or other severe heart diseases. * Organ Function: Normal function of major organs, meeting the following laboratory criteria: Absolute neutrophil count (ANC) ≥ 1.5 x 10\^9/L without granulocyte colony-stimulating factor for the past 14 days. Platelet count ≥ 100 x 10\^9/L without transfusion for the past 14 days. Hemoglobin \> 9 g/dL without transfusion or erythropoietin use for the past 14 days. Total bilirubin ≤ 1.5 x upper limit of normal (ULN); if \> 1.5 x ULN, direct bilirubin must be ≤ ULN. AST and ALT ≤ 2.5 x ULN. Serum creatinine ≤ 1.5 x ULN and creatinine clearance (using Cockcroft-Gault formula) ≥ 60 ml/min. Normal coagulation function (INR or PT ≤ 1.5 x ULN). Normal thyroid function (TSH within normal range, or normal T3/FT3 and FT4 if baseline TSH is out of range). Normal myocardial enzyme spectrum (clinical judgment for non-significant lab abnormalities is acceptable). * Weight: Body weight ≥ 40 kg or BMI \> 18.5. * Female Patients: Must be post-menopausal (no menses for at least one year without other causes) or surgically sterilized (removal of ovaries and/or uterus). Women of childbearing potential must have a negative pregnancy test within 7 days prior to the first dose. Agree to use highly effective contraception (annual failure rate \< 1%) or abstain from heterosexual intercourse from the time of informed consent until at least 120 days after the last dose of the study drug or 9 months after surgery. * Male Patients: Must agree to use contraception or abstain from heterosexual intercourse from the time of informed consent until at least 120 days after the last dose of the study drug or 9 months after surgery. Regular abstinence (e.g., calendar, ovulation, basal body temperature, or post-ovulation methods) and withdrawal are not acceptable forms of contraception. * Informed Consent: Patients must read, understand, and sign the informed consent form. Exclusion Criteria: * Other Malignancies: Patients with a history of other malignancies within the past 5 years or concurrent malignancies. Exceptions include cured localized tumors such as basal cell carcinoma of the skin, squamous cell carcinoma of the skin, superficial bladder cancer, in situ prostate cancer, in situ cervical cancer, in situ breast cancer, stage I lung cancer, and stage I colorectal cancer. Transplant Patients: Patients planning to undergo or having previously undergone organ or bone marrow transplantation. Blood Transfusions and Bleeding: Patients who have received a blood transfusion within 2 weeks before the first dose, have a history of bleeding, or experienced any severe bleeding events (grade 3 or higher per CTCAE 4.0) within 4 weeks before screening. Coagulation Disorders: Patients with coagulation abnormalities and bleeding tendencies (INR \> 1.5 without anticoagulants). Patients on anticoagulants or vitamin K antagonists like warfarin, heparin, or similar drugs can participate if INR ≤ 1.5, small-dose warfarin (1 mg/day) or aspirin (≤ 100 mg/day) is allowed for preventive use. Thromboembolic Events: Patients with arterial/venous thromboembolic events within 6 months before screening, such as stroke (including transient ischemic attacks), deep vein thrombosis (excluding cases resolved post-chemotherapy), and pulmonary embolism. Cardiac Conditions: Patients with myocardial infarction, uncontrolled arrhythmias (including QTc interval ≥ 450 ms for males and ≥ 470 ms for females, using the Fridericia formula) within 6 months before the first dose. NYHA class III-IV heart failure or LVEF \< 50% on echocardiogram. Proteinuria: Urinalysis indicating proteinuria ≥ ++ and 24-hour urine protein \> 1.0 g. Oral Drug Absorption Issues: Factors affecting oral drug absorption (e.g., inability to swallow, chronic diarrhea, bowel obstruction). Pleural or Peritoneal Effusion: Clinically significant pleural or peritoneal effusion requiring intervention. HIV Infection: Patients with HIV infection. Active Tuberculosis: Patients with active tuberculosis. Non-Healing Wounds or Fractures: Patients with long-standing unhealed wounds or incomplete healing of fractures. Lung Diseases: Patients with interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonitis, or severely impaired lung function that could interfere with the detection and treatment of suspected drug-related pulmonary toxicity. Autoimmune Diseases: Patients with known active or suspected autoimmune diseases, except those in a stable state without systemic immunosuppressive treatment. Chronic Autoimmune Diseases: Severe chronic autoimmune diseases such as systemic lupus erythematosus; patients with a history of ulcerative colitis, Crohn's disease, or irritable bowel syndrome; history of sarcoidosis or tuberculosis; active hepatitis B or C, and HIV infection. Well-controlled non-severe autoimmune diseases like dermatitis, arthritis, psoriasis can be included. Patients with hepatitis B virus titers \< 500 copies/ml can participate. Immunosuppressive Treatment: Patients requiring systemic corticosteroids (\> 10 mg/day prednisone equivalent) or other immunosuppressive drugs within 14 days before the first dose or during the study. Localized topical or inhaled steroids or adrenal hormone replacement therapy (≤ 10 mg/day prednisone equivalent) are allowed. Active Infections: Active infections requiring systemic treatment within 14 days before the first dose. Preventive antibiotic treatment (e.g., for urinary tract infection or COPD) is allowed. Live Vaccines: Patients who have received live vaccines within 28 days before the first dose. Inactivated viral vaccines for seasonal flu are allowed. Previous Checkpoint Inhibitors: Patients previously treated with checkpoint inhibitors like PD-1, PD-L1, or CTLA-4 inhibitors. Immunomodulatory Treatments: Patients who received immunomodulatory treatments (e.g., thymopentin, thymalfasin, interferons, CAR-T therapy) within 6 months before the first dose. Other Clinical Studies: Patients currently receiving other clinical study treatments or planning to start this study treatment within one month of completing a previous clinical study treatment. Drug Allergies: Known allergy or intolerance to any study drug or its components. Substance Abuse: History of alcohol, drug, or substance abuse. Patients who have stopped drinking can be included. Compliance Issues: Patients who are non-compliant with medical instructions, prescribed medications, or have incomplete records affecting efficacy or safety assessments. Pregnancy and Breastfeeding: Pregnant or breastfeeding women. High-Risk Factors: Patients with conditions increasing the risk of study participation or study drug use, or other severe, acute, or chronic diseases deemed unsuitable by the investigator. Investigator Discretion: Any other conditions that the investigator deems unsuitable for the clinical trial.

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2024-06-17