Association of Osteopontin Gene Polymorphisms With Susceptibility and Prognosis of Ischemic Stroke in Egyptian Patients

Gene polymorphisms in stroke

This study aims to investigate the correlation of serum osteopontin level as a predictior and a prognostic factor in upper egyptian patients and correlation between Osteopontin Gene Polymorphisms and serum level of osteopontin in ischaemic stroke patients

2024-09-01

2024-09-01

2025-10-01

Not yet recruiting

100

Inclusion Criteria: * For acute ischemic stroke cases: ( Acute ischemic stroke will be defined as an episode of focal neurological deficits lasting for more than 24 hour with relevant lesion in brain computerized tomography (CT) or magnetic resonance (MR) image\>) 1- both sex 2- Age between 18 to 70 years old. 3-symptoms suggestive of acute ischemic stroke: presenting within 24 hours of onset of these symptoms * For old ischemic stroke: 1. both sex 2. Age between 18 to 70 years old. 3. Duration of3to 6 month of development of ischemic symptoms * For control cases: 1. both sex 2. Healthy people 3. Age: above 18 years old Exclusion Criteria: Patients with a previous history of stroke; Patients with hemorrhagic stroke. Patients with coronary heart disease, heart failure, chronic inflammation, intracranial infection/brain tumor and malignant tumor. Patients with liver, kidney and other important organ dysfunction. Patients with severe abnormal coagulation function

{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'CASE_CONTROL', 'timePerspective': 'PROSPECTIVE'}, 'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Blood samples will be collected from stroke patients within 24 hrs of stroke and normal volunteers.\n\nTwo samples will be collected serum and plasma; five ml whole blood from patients and normal volunteers and centrifuge serum samples at 1500 rpm 10 min then will be stored at - 80 °C until the day of the analysis.\n\nPlasma samples will be stored at - 80 °C until the day of the analysis without centrifugation'}, 'enrollmentInfo': {'count': 100, 'type': 'ESTIMATED'}}

2024-06-17