Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor

Dobutamine

Septic shock is the last and most severe stage of sepsis and is defined by extremely low blood pressure, despite lots of intravenous fluids. The incidence of septic shock related cardiomyopathy was 10% to 70%. Besides, general anesthesia will inhibit the sympathetic nervous system, reduce myocardial contractility and aggravate cardiac dysfunction. No randomized controlled trials have yet explore the effects of dobutamine on clinical outcomes for patients with septic shock undergoing surgery under general anesthesia.

2024-06-20

2027-04-30

2027-04-30

Not yet recruiting

584

Inclusion Criteria: 1. Patients with 18 years or older 2. Sugery patients with septic shock and the duration of opration is more than 1 hour Exclusion Criteria: 1. Pregnancy; 2. Patients with a history of Cardiac insufficiency; 3. Patients with acute coronary syndrome within the last 3 months; 4. Patients with severe valvular heart disease; 5. Patients with chronic renal insufficiency; 6. Long-term intakeβ-receptor blocker; 7. Patients use Recombinant Human Brain Natriuretic Peptide(rhBNP), Levosimendan and Epinephrine within 24 hour before the sugery; 8. Patients with hyperthyroidism; 9. Allergy or known sensitivity to catecholamines（norepinephrine, dobutamine etc.）and genera anesthetics. 10. Patients and guardians refused to participate in this intervention clinical trial.

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 584, 'type': 'ESTIMATED'}}

2024-06-17