Evaluation of Inflammasome Gene Polymorphisms in Patients With Stage III, Grade B and C Periodontitis

09-2023-1700

The present study aimed to evaluate the distribution of NLRP3, AIM2, and IFI16 inflammasome gene polymorphisms in individuals with Stage III Grade B and C periodontitis and periodontally healthy individuals. 80 periodontally healthy, 80 Stage III Grade B and 80 Stage III Grade C periodontitis patients will be enrolled. Blood samples will be collected from each participants and clinical parameteres will be recorded for whole mouth. DNA isolation will be performed from all samples. The SNP regions with the numbers rs4612666, rs75985579, and rs2793845 will be detected from DNA material using Real-Time PCR device genotyping kits. Data will be analyzed using statistical tests.

2024-07-01

2025-04-14

2025-04-14

Recruiting

240

Inclusion Criteria: * systematically healthy, non-smoker individuals * patients between the ages of 18 and 65 * individuals with periodontally healthy, stage III grade B and C periodontitis diagnoses Exclusion Criteria: * having any diagnosed medical disorders such as diabetes mellitus, cardiovascular diseases, rheumatoid arthritis... * Usage of antibiotics, non-steroidal anti-inflammatory drugs and immunosuppressive agents within the past 6 months. * Periodontal treatment within the preceding 6 months. * Pregnant/ lactating/ postmenopausal females. * Current orthodontic treatment.

{'studyType': 'OBSERVATIONAL', 'patientRegistry': True, 'targetDuration': '1 Day', 'designInfo': {'observationalModel': 'CASE_CONTROL', 'timePerspective': 'CROSS_SECTIONAL'}, 'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Whole Blood'}, 'enrollmentInfo': {'count': 240, 'type': 'ESTIMATED'}}

2024-06-18