Clinical trial
IcoSApent ethyL to Slow Down Aortic VAlve Stenosis proGrEssion
Name
NL81780.018.22
Description
This study invastigates the effect of icosapent ethyl in patients with aortic valve stenosis.
Trial arms
Trial start
2023-06-01
Estimated PCD
2026-07-01
Trial end
2026-12-01
Status
Recruiting
Phase
Early phase I
Treatment
Icosapent ethyl
2dd2
Arms:
Medication
Placebo
2dd2
Arms:
Placebo
Size
110
Primary endpoint
Change in aortic valve calcium (AVC) score
2 years
Eligibility criteria
Inclusion Criteria:
1. Age \> 50 years
2. Mild to moderate AVS
Exclusion Criteria:
1. Bicuspid aortic valve
2. History of chest radiotherapy
3. History of rheumatic fever
4. Moderate to severe renal failure, defined as eGFR \< 30 ml/min
5. Hyperparathyroidism
6. Paget's disease
7. Diagnosis of (active) malignancy in last 5 years
8. Anticipated or planned aortic valve surgery in the next 6 months
9. Life expectancy \<2 years
10. Chronic atrial fibrillation
11. Use of anticoagulant medication or dual antiplatelet therapy
12. Known hypersensitivity to fish and/or shellfish
13. Known hypersensitivity to soya
14. Malabsorption syndrome and/or chronic diarrhea
15. Women of childbearing potential who are unwilling or unable to use an acceptable method of birth control \[such as oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (condoms)\] to avoid pregnancy for the entire study.
16. Women who are pregnant or breastfeeding
17. Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
18. Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 110, 'type': 'ESTIMATED'}}
Updated at
2024-06-19
1 organization
1 product
1 drug
1 indication
Product
Icosapent ethylIndication
Aortic Valve StenosisDrug
Varlilumab