Clinical trial
Effect of Botulinum Toxin on Hamstring Contracture and the Occurrence of Cyclops Syndrome After Anterior Cruciate Ligament Reconstruction
Name
2020-005742-42
Description
Monocentric, prospective, randomised, double-blind study of two parallel groups of 66 patients with post-reconstruction ACL hamstring contracture treated with an ultrasound-guided injection at two points on the body of the hamstring
* Group 1: botulinum toxin: 100 units (0.5ml) in 1 injection
* Group 2: placebo: 0.5 ml in 1 injection
Trial arms
Trial start
2024-07-02
Estimated PCD
2026-01-01
Trial end
2026-01-01
Status
Not yet recruiting
Phase
Early phase I
Treatment
Botulinum toxin
100 units (0.5ml) in 1 injection
Arms:
Group 1
Placebo
Placebo 0.5 ml in 1 injection
Arms:
Group 2
Size
132
Primary endpoint
The percentage of therapeutic success, defined by the absence of extension defect at M3 post ligamentoplasty, will be compared between the groups by a Chi-2 test.
Month 2
Eligibility criteria
Inclusion Criteria:
* Patient over 18 years of age
* Patient who has read and signed the consent form for participation in the study
* Patient operated on for primary ACL ligamentoplasty with or without meniscal repair
* Patient with reducible flatus \>10° at 1 month post ligamentoplasty
Exclusion Criteria:
* Revision ligamentoplasty
* Multi-ligament knee
* Patient under court protection, guardianship or trusteeship
* Patient not affiliated to the French social security system
* Patient participating in another therapeutic protocol
* Pregnant woman or woman of childbearing age without effective contraception
* Patient unable to understand the informed information and/or to give written informed consent: dementia, psychosis, disturbed consciousness, non-French speaking patient
* Patient with known hypersensitivity to botulinum toxin
* Patient with peripheral neuromuscular dysfunction or pronounced atrophy of the semitendinosus muscle
* Patient treated with anticoagulants, chloroquine (or hydroxychloroquine)
* Patient treated in the previous seven days with antibiotics or muscle relaxants (such as tubocurarine)
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Monocentric, prospective, randomised, double-blind study of two parallel groups of 66 patients with post-reconstruction ACL hamstring contracture treated with an ultrasound-guided injection at two points on the body of the hamstring\n\n* Group 1: botulinum toxin: 100 units (0.5ml) in 1 injection\n* Group 2: placebo: 0.5 ml in 1 injection', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'maskingDescription': 'A placebo is used', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 132, 'type': 'ESTIMATED'}}
Updated at
2024-07-01
1 organization
1 product
1 indication
Product
Botulinum toxinIndication
Hamstring Contractures