Real-World Medication Adherence Trajectories to Nintedanib Among Idiopathic Pulmonary Fibrosis Patients

1199-0471

This is a non-interventional cohort study using existing administrative data from the U.S. Medicare program. This study has two objectives: * Identification of adherence trajectories of nintedanib among Idiopathic Pulmonary Fibrosis (IPF) patients. * Understanding characteristics of patients within each nintedanib adherence trajectory among IPF patients.

2021-08-23

2021-12-30

2021-12-30

Completed

1798

Inclusion criteria: * Newly initiated nintedanib during 10/01/2014 to 12/31/2018 * Were at least 66 years old as of the date of their first nintedanib prescription claim (index date) * Qualified for Medicare based on age * Had at least 12 months (365 days) of continuous enrollment in Medicare Parts A, B and D before (baseline period) and 12 months (360 days) after the index date (follow-up period) * Had at least one inpatient or two outpatient claims (\>14 days apart) with a diagnosis code for Idiopathic Pulmonary Fibrosis (IPF) during the baseline period Exclusion criteria: * Had any history of pirfenidone or nintedanib use during the baseline period * Had any history of lung transplant during the baseline, index date or follow-up periods * Had any claims for skilled nursing facility, long-term care facility or hospice during the baseline, index date or follow-up period * Had evidence during the baseline period of any of the following conditions: lung cancer, autoimmune, or connective tissue diseases (i.e. rheumatoid arthritis (RA), sarcoidosis, systemic lupus erythematosus (SLE), dermatopolymyositis, systemic sclerosis, Sjogren's, and mixed connective tissue disease (CTD)) during the baseline period * Had dual eligibility of Medicare and Medicaid * Had history of using pirfenidone at the same time with nintedanib during follow-up

{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'RETROSPECTIVE'}, 'enrollmentInfo': {'count': 1798, 'type': 'ACTUAL'}}

2024-04-19