Clinical trial
A Phase 2a, Multicenter, Open-Label Study to Evaluate the Safety and Efficacy of AT-1501 in Patients With IgA Nephropathy
Name
AT-1501-N205
Description
This is a phase 2a, multicenter, open-label study designed to evaluate the safety and efficacy of AT-1501 in patients with biopsy proven IgAN and at least 0.75 g/24 hours of protein in their urine at the time of screening.
Trial arms
Trial start
2022-03-21
Estimated PCD
2023-07-31
Trial end
2023-07-31
Status
Terminated
Phase
Early phase I
Treatment
AT-1501
AT-1501 monoclonal antibody targeting CD40L given as an IV infusion
Arms:
Arm A, Arm B
Size
24
Primary endpoint
Efficacy - change in participants UPCR
Up to 24 weeks
Safety- Number of participants with treatment related adverse events
Through study completion, an average of 100 weeks
Eligibility criteria
Inclusion Criteria:
1. Male or female ≥ 18 years of age
2. Biopsy proven IgAN
3. Urine protein ≥ 0.75g/24 hours at Screening despite optimization with ACE inhibitors or angiotensin receptor blockers (ARB)
4. eGFR ≥ 45 mL/min per 1.73 m2 or eGFR \< 45 mL/min per 1.73 m2 and ≥ 30 mL/min per 1.73 m2 with a kidney biopsy within 2 years of Screening showing \< 50% tubulointerstitial fibrosis
5. Agree to comply with contraception requirements during and for 90 days after study completion.
Exclusion Criteria:
1. Any secondary IgAN as defined by the investigator
2. Patients who have undergone a kidney transplant
3. Any history of kidney disease other than IgAN
4. Any history of diabetes (Type 1 or Type 2)
5. Seated blood pressure \> 140 mmHg (systolic) or \> 90 mmHg (diastolic) at the Screening Visit. Patients must be on a stable dose and regimen of an ACE inhibitor or ARB for at least 90 days
6. Pregnancy or breastfeeding.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NON_RANDOMIZED', 'interventionModel': 'SEQUENTIAL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 24, 'type': 'ACTUAL'}}
Updated at
2024-03-26
1 organization
1 product
2 indications
Product
AT-1501Indication
IgA NephropathyIndication
IgA nephropathyOrganization
Eledon Pharmaceuticals