Randomized Trial of Mefenamic Acid Versus Tranexamic Acid in Management of Abnormal Uterine Bleeding

Rania Gamal

Abnormal uterine bleeding "AUB" describes all abnormal forms of menstrual bleeding which may result from several causes including anovulation, problems related to pregnancy, infections, vaginal and cervical abnormalities, uterine pathologies including benign and malignant tumors, coagulopathies, endocrine disorders, trauma, foreign bodies, systemic diseases and iatrogenic causes. AUB may be clinically presented by menorrhagia, metrorrhagia or menometrorrhagia. It's the most common complaint for the reproductive age females and accounts for 33% of female patients referred to gynecologists

2024-03-01

2024-09-01

2024-09-30

Recruiting

130

Inclusion Criteria: * Any female patient in Child bearing period aging from 15-45 years complaining of Abnormal uterine. * Abnormal uterine bleeding due to endometrial, uterine cavity lesions as diagnosed by TVS or bleeding tendency e.g. Thrombocytopenia, Platelets dysfunction and coagulation defects Exclusion Criteria: * Personal history of renal or hepatic impairment; previous thromboembolic disease, peptic ulcer. * Females with evident drugs intake that cause AUB e.g warfarin, low molecular weight heparin. * Vaginal, vulvar, and cervical causes of bleeding. * Bleeding on top of Use of hormonal and non-hormonal contraception.

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER']}}, 'enrollmentInfo': {'count': 130, 'type': 'ESTIMATED'}}

2024-04-16