Clinical trial
A Randomized, Double-blind, Double-dummy, Parallel Group Trial Comparing 12 Weeks Treatment With Tiotropium Inhalation Capsules 18 mcg Via the HandiHaler® Once Daily to Combivent® Inhalation Aerosol CFC MDI 2 Actuations q.i.d. in COPD Patients Currently Prescribed Combivent® Inhalation Aerosol CFC MDI
Name
205.346
Description
The objective of this study is to evaluate the efficacy and safety of 12 weeks treatment with tiotro pium HandiHaler® 18 mcg daily compared to Combivent® MDI CFC Inhalation Aerosol 2 actuations qid in COPD patients currently prescribed Combivent® MDI.
Trial arms
Trial start
2006-10-04
Estimated PCD
2007-10-08
Phase
Early phase I
Treatment
tiotropium
ipratropium bromide / albuterol
Size
327
Primary endpoint
Trough FEV1
after 12 weeks of treatment
FEV1 AUC0-6 hours
after 12 weeks of treatment
Eligibility criteria
Inclusion Criteria:
* Diagnosis of COPD
* Age: \>= 40 years
* Current or ex-smoker with a \>= 10 pack-year smoking history
* Use of Combivent® MDI for \>= 1 month prior to Visit 1 Spirometric criteria (determined at study visits):
* Post-bronchodilator FEV1 \<= 70% (Visit 1)
* Pre-bronchodilator FEV1 \<= 65% of predicted and FEV1/FVC \<= 70% (Visit 2)
Exclusion Criteria:
* Clinical history of asthma
* History of thoracotomy with pulmonary resection
* History of CF, alpha 1 antitrypsin deficiency or interstitial lung disease
* Daytime use of oxygen therapy for \> 1 hour per day or if unable to abstain from using oxygen during PFTs
* Any respiratory tract infection or COPD exacerbation in 6 weeks prior to Visit 1
* Recent history 6 months or less of MI
* Unstable or life-threatening cardiac arrhythmias
* Hospitalization for CHF during past year
* Malignancy for which patient is receiving chemo or radiation therapy
* Pregnant or nursing women
* Known hypersensitivity to ipratropium or carrier substances, including related food products such as soybean, peanuts, or lactose
* Use of SPIRIVA® 3 months prior to Visit 1
* Symptomatic of prostatic hypertrophy or bladder neck obstruction
* Known narrow- angle glaucoma
* Participating in a pulmonary rehab program within 4 weeks of Visit 1
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'primaryPurpose': 'TREATMENT'}, 'enrollmentInfo': {'count': 327, 'type': 'ACTUAL'}}
Updated at
2023-12-01
1 organization
2 products
2 indications
Organization
Boehringer IngelheimProduct
tiotropiumIndication
Pulmonary DiseaseIndication
Chronic Obstructive