Clinical trial
Induction of Donor Specific Tolerance in Recipients of Living Kidney Allografts by Donor FCRx Infusion
Name
FCR001A2201
Description
An open-label study to assess the safety, efficacy, and tolerance of FCRx cell therapy in adult recipients within 12 months after kidney transplantation from a living donor.
Trial arms
Trial start
2008-03-01
Estimated PCD
2023-03-01
Trial end
2023-04-01
Status
Terminated
Phase
Early phase I
Treatment
Enriched Hematopoietic Stem Cell Infusion
Enriched Hematopoietic Stem Cell Infusion
Arms:
Living Kidney Allograft
Size
37
Primary endpoint
Enriched Hematopoietic Stem Cell Engraftment
One month to three years
Eligibility criteria
Inclusion Criteria:
* Patient must be between the ages of 18 and 65 years and meet the institution's criteria for renal transplantation for end-organ failure
* Meets the transplant criteria by the study site and both the recipient and donor have been accepted as candidates for standard of care living kidney donation and transplantation
* Patient is receiving a renal transplant only
* The crossmatch is negative between donor and recipient. An initial crossmatch will be performed prior to stem cell mobilization to determine if subject can proceed with the apheresis.
* Potential recipients who are women of child bearing potential must have a negative pregnancy test (urine test is acceptable) within 48 hours prior to receiving Granulocyte colony-stimulating factor (G-CSF) and agree to use reliable contraception for 1 year following FCRx infusion
* Potential donors who are women of child bearing potential must have a negative pregnancy test (urine test is acceptable) within 48 hours prior to receiving G-CSF
* No evidence of donor-specific antibody presently or historically
* Panel Reactive Antibody (PRA) less than or equal to 20
Note: The subjects do not need to be local residents in order to be eligible for this trial, but must be willing to reside in the area, or within a four-hour drive, for the first month of the protocol so that they can be monitored closely in the early post-transplant period.
Exclusion Criteria:
* Clinically active bacterial, fungal, viral or parasitic infection
* Pregnancy
* Clinical or serologic evidence of viral infection which would preclude the recipient from receiving a kidney transplant or FCRx infusion
* Previous radiation therapy at a dose which would preclude Total Body Irradiation (TBI)
* Positive crossmatch between donor and recipient
* Evidence for immunologic memory against donor
* Body Mass Index (BMI) \>35 or \<18
* Positive serologies for Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), human immunodeficiency virus (HIV)
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 37, 'type': 'ACTUAL'}}
Updated at
2023-10-11
1 organization
1 product
1 indication
Organization
Talaris TherapeuticsIndication
Kidney Failure