Clinical trial
A Phase III, Multicenter, Randomized, Double-blind, Active Controlled Trial of RC28-E Intravitreal Injection in Subjects With Diabetic Macular Edema
Name
28C005
Description
The purpose of this study is to evaluate efficacy and safety of RC28-E compared with Aflibercept in subjects with diabetic macular edema.
Trial arms
Trial start
2023-06-08
Estimated PCD
2026-06-01
Trial end
2026-06-01
Status
Recruiting
Phase
Early phase I
Treatment
RC-28E
Ophthalmic solution for intravitreal injection administered as a 2.0mg/50 μL per dose.
Arms:
RC-28E
Aflibercept
Ophthalmic solution for intravitreal injection administered as a 2.0mg/50 μL per dose.
Arms:
Aflibercept
Size
316
Primary endpoint
Change from baseline in BCVA at Week 52
Baseline, week 52
Eligibility criteria
Inclusion Criteria:
* Documented diagnosed with type I or type II diabetes mellitus.
* Hemoglobin A1c (HBA1c) of less than or equal to (≤) 10% within 2 months prior to Day 1.
* Ability and willingness to undertake all scheduled visits and assessments.
* The study eye must meet the following requirements:
* macular thickening secondary to diabetic macular edema (DME) involving the center of the fovea.
* decreased visual acuity attributable primarily to DME, the best corrected visual acuity (BCVA) 19 or more letters, 78 letters or less.
Exclusion Criteria:
* The study eye with high risk of proliferative diabetic retinopathy.
* The macular edema of the study eye is mainly caused by other diseases or factors other than DME.
* Treatment with panretinal photocoagulation or macular laser within 3 months prior to Day 1 to the study eye.
* Administration of IVT any other anti-VEGF drugs in the study eye within 3 months and/or in the other eye within 7 days prior to Day 1.
* Any intraocular long-acting or sustained release corticosteroid treatment (e.g., dexamethasone intravitreal implant) in the study eye within 6 months prior to Day 1.
* Active intraocular or periocular infection or active intraocular inflammation in either eye.
* The study eye with poorly controlled glaucoma.
* A history of idiopathic or autoimmune related uveitis in either eye.
* History of stroke (cerebrovascular accident) or myocardial infarction within 6 months prior to Day 1.
* Uncontrolled blood pressure, defined as a systolic value greater than (\>)180 millimeters of mercury (mmHg) and/or a diastolic value \>100 mmHg while a patient is at rest.
* Currently pregnant or breastfeeding, or intend to become pregnant during the study.
* Any current or history of ocular disease other than DME that may confound assessment of the macula or affect central vision in the study eye.
* Any current ocular condition which, in the opinion of the investigator, is currently causing or could be expected to contribute to irreversible vision loss due to a cause other than DME in the study eye.
* Other protocol-specified inclusion/exclusion criteria may apply.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 316, 'type': 'ESTIMATED'}}
Updated at
2023-09-05
1 organization
2 products
1 indication
Organization
RemeGenProduct
AfliberceptIndication
Diabetic Macular EdemaProduct
RC-28E