Clinical trial
A Phase 1b/2, Open-label, Multi-center Study of ERAS-007 (ERK Inhibitor) Administered as Monotherapy or in Combination With ERAS-601 (SHP2 Inhibitor) in Patients With Advanced or Metastatic Solid Tumors (HERKULES-1)
Name
ERAS-007-01
Description
* To evaluate the safety and tolerability of ERAS-007 monotherapy administered once weekly (QW) and twice daily-once weekly (BID-QW).
* To determine the Maximum Tolerated Dose (MTD) and/or Recommended Dose (RD) of ERAS-007 monotherapy administered BID-QW.
* To characterize the pharmacokinetic (PK) profile of ERAS-007 monotherapy.
* To determine the optimal dose and schedule of ERAS-007 monotherapy.
* To evaluate antitumor activity of ERAS-007 in various solid tumors.
* To evaluate the safety and tolerability of ERAS-007 (BID-QW) and ERAS-601 (twice daily for three weeks on and 1 week off (BID 3/1)) when administered in combination.
* To determine the Maximum Tolerated Dose (MTD) and/or Recommended Dose (RD) of ERAS-007 administered in combination with ERAS-601.
* To characterize the pharmacokinetic (PK) profile of ERAS-007 and ERAS-601 when administered in combination.
* To evaluate antitumor activity of ERAS-007 and ERAS-601 when administered in combination in various solid tumors
* To evaluate antitumor activity of ERAS-007 and ERAS-601 when administered in combination in various solid tumors
Trial arms
Trial start
2021-05-07
Estimated PCD
2024-05-01
Trial end
2024-11-01
Status
Active (not recruiting)
Phase
Early phase I
Treatment
ERAS-007
ERAS-007 will be administered orally as specified in Arm description.
Arms:
Dose Escalation (Part A): ERAS-007 Monotherapy, BID-QW dosing, Dose Escalation (Part D): ERAS-007 BID-QW dosing in combination with ERAS-601, Dose Expansion (Part B): ERAS-007 Monotherapy, QW dosing, Dose Expansion (Part C): ERAS-007 Monotherapy, BID-QW dosing (if necessary)
ERAS-601
ERAS-601 will be administered orally as specified in Arm description.
Arms:
Dose Escalation (Part D): ERAS-007 BID-QW dosing in combination with ERAS-601
Size
200
Primary endpoint
Evaluate safety and tolerability of escalating doses of ERAS-007 BID-QW
Assessed up to 24 months from time of first dose
Dose Limiting Toxicities (DLT)
Study Day 1 up to Day 29
Maximum tolerated dose (MTD)
Study Day 1 up to Day 29
Recommended dose (RD)
Study Day 1 up to Day 29
Adverse Events
Assessed up to 24 months from time of first dose
Plasma concentration (Cmax)
Study Day 1 up to Day 29
Time to achieve Cmax (Tmax)
Study Day 1 up to Day 29
Area under the curve
Study Day 1 up to Day 29
Half-life
Study Day 1 up to Day 29
Eligibility criteria
Inclusion Criteria:
* Age ≥ 18 years.
* Willing and able to give written informed consent.
* Have histologically or cytologically confirmed advanced or metastatic solid tumor with a relevant molecular alteration (as applicable).
* There is no available standard systemic therapy available for the patient's tumor histology and/or molecular biomarker profile; or standard therapy is intolerable, not effective, or not accessible; or patient has refused standard therapy.
* Recovered from all toxicities associated with prior treatment to acceptable baseline status.
* Have ECOG performance status of 0 or 1 with an anticipated life expectancy of \> 12 weeks.
* Willing to comply with all protocol-required visits, assessments, and procedures.
* Able to swallow oral medication.
Exclusion Criteria:
* Currently receiving another study therapy or has participated in a study of an investigational agent and received study therapy within 4 weeks of the first dose of ERAS-007.
* Received previous treatment with an ERK inhibitor.
* For participants being considered for ERAS-007 + ERAS-601 (Part D): prior treatment with SHP2 inhibitor.
* For participants being considered for ERAS-007 + ERAS-601 (Part D): documented PTPN11 mutations
* Received prior antineoplastic therapy within \< 21 days or 5 half-lives, whichever is shorter.
* Received prior palliative radiation within 7 days of first dose of ERAS 007 or ERAS-601,
* Received previous treatment with a MAPK inhibitor that resulted in discontinuation due to unacceptable toxicity.
* Prior surgery (e.g., gastric bypass surgery, gastrectomy) or gastrointestinal dysfunction (e.g., Crohn's disease, ulcerative colitis, short gut syndrome) that may affect drug absorption.
* Have any underlying medical condition, psychiatric condition, or social situation that, in the opinion of the Investigator, would compromise study administration as per protocol or compromise the assessment of AEs.
* Are pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the trial.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1', 'PHASE2'], 'designInfo': {'allocation': 'NON_RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 200, 'type': 'ESTIMATED'}}
Updated at
2023-06-06
1 organization
2 products
1 indication
Organization
ErascaProduct
ERAS-007Indication
Advanced or Metastatic Solid TumorsProduct
ERAS-601