Clinical trial
A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Phase 3 Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Treatment of Presbyopia
Name
JX07001
Description
Phase 3 Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Treatment of Presbyopia
Trial arms
Trial start
2023-09-27
Estimated PCD
2024-07-31
Trial end
2024-12-31
Status
Recruiting
Phase
Early phase I
Treatment
Aceclidine+Brimonidine combination ophthalmic solution
Aceclidine+Brimonidine combination ophthalmic solution
Arms:
LNZ101 (Aceclidine/Brimonidine) ophthalmic solution
Other names:
LNZ101
Aceclidine ophthalmic solution
Aceclidine ophthalmic solution
Arms:
LNZ100 (Aceclidine) ophthalmic solution
Other names:
LNZ100
Placebo (Vehicle) ophthalmic solution
Placebo (Vehicle) ophthalmic solution
Arms:
Placebo (Vehicle) ophthalmic solution
Size
300
Primary endpoint
Best-corrected distance visual acuity (BCDVA) at 40 cm
3 hours post-treatment in the study eye at Visit 2 (Day 1)
Eligibility criteria
Inclusion Criteria:
1. Be able and willing to provide written informed consent prior to any study procedure being performed;
2. Be able and willing to follow all instructions and attend all study visits;
3. Be 45-75 years of age of either sex at Visit 1;
4. Have +1.00 to -4.00 diopter (D) of sphere calculated in minus cylinder in both eyes determined by manifest refraction documented at Visit 1;
5. Have ≤2.00 D of cylinder (minus cylinder) in both eyes determined by manifest refraction documented at Visit 1;
6. Have +1.00 D to -4.00 D manifest refraction spherical equivalent(MRSE)of Spherical equivalent (SE) determined by manifest refraction documented at Visit 1.
7. Be presbyopic as determined at Visit 2 baseline
Exclusion Criteria:
1. Be a female of childbearing potential who is currently pregnant, nursing, or planning a pregnancy;
2. Have known contraindications or sensitivity to the use of any of the study medications or their components;
3. Have an active ocular infection at Visit 1 or at Visit 2 (bacterial, viral, or fungal), positive history of an ocular herpetic infection, preauricular lymphadenopathy, or ongoing, active ocular inflammation (e.g., moderate to severe blepharitis, allergic conjunctivitis, peripheral ulcerative keratitis, scleritis, uveitis) in either eye;
4. Have moderate or severe dry eye at Visit 1, assessed by corneal fluorescein staining;
5. Have clinically significant abnormal lens findings (e.g., cataract) including early lens changes and/or any evidence of a media opacity during dilated slitlamp biomicroscopy and fundus exam documented within 3 months of Visit 1 or at Visit 1;
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 300, 'type': 'ESTIMATED'}}
Updated at
2023-10-26
1 organization
3 products
3 indications
Organization
Ji Xing Pharmaceuticals (Shanghai)Product
AceclidineIndication
PresbyopiaIndication
MiosisIndication
Eye DisordersProduct
Aceclidine + BrimonidineProduct
Placebo