Clinical trial
A Randomized, Double-blind, Placebo-controlled, 2-way Cross-over Trial Evaluating the Effect of C21 on Endothelial Dysfunction and Safety in Subjects With Type 2 Diabetes Mellitus
Name
VP-C21-013
Description
This trial is a single-centre, randomized, double-blind, placebo-controlled, 2-way cross-over phase 1b trial evaluating the pharmacodynamic effect of C21 on endothelial dysfunction and safety in subjects with type 2 diabetes mellitus (T2DM).
Trial arms
Trial start
2023-04-25
Estimated PCD
2023-06-16
Trial end
2023-06-20
Status
Completed
Phase
Early phase I
Treatment
C21
C21 is an angiotensin II type 2 receptor agonist (ATRAG)
Arms:
Treatment arm 1, Treatment arm 2
Size
11
Primary endpoint
Pharmacodynamic effect
Maximum 15 days after first Investigational Medical Product (IMP) intake.
Eligibility criteria
Inclusion Criteria:
* Male or female patient aged ≥ 40 years at the time of the screening visit (Visit 1).
* Documented diagnosed with T2DM prior to the screening visit (Visit 1).
* An RHI score ≤ 2 as assessed by EndoPAT at the time of the screening visit (Visit 1).
Exclusion Criteria:
* Known, active hepatitis B, C, or human immunodeficiency virus (HIV) infection (i.e., HIV with a CD4 (cluster of differentiation 4) count \<500 cells/mm³).
* Impaired hepatic function or clinically significant liver disease, which in the investigator's opinion makes the subject inappropriate for this trial.
* Severe renal impairment (i.e., estimated glomerular filtration rate (eGFR) ≤30 mL/min/1.73 m2).
* Prolonged QTcF (QT interval with Fridericia's correction) (\>450 ms), atrial fibrillation, clinically significant arrhythmia or other clinically significant abnormality in the resting ECG (electrocardiogram) at screening (Visit 1), as judged by the investigator.
* Unstable or deteriorating cardiac condition.
* Malignancy within the past 5 years with the exception of in situ removal of basal cell carcinoma and cervical intraepithelial neoplasia grade I.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'CROSSOVER', 'primaryPurpose': 'BASIC_SCIENCE', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 11, 'type': 'ACTUAL'}}
Updated at
2023-08-04
1 organization
1 product
2 indications
Organization
Vicore PharmaProduct
C21Indication
Type 2 diabetesIndication
Endothelial dysfunction