Clinical trial
A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Describe Pharmacokinetics/Pharmacodynamics, and the Safety and of SPH3127 Tablet in Chinese Healthy Volunteers
Name
SPH3127-101
Description
1. To evaluate safety, tolerability and pharmacokinetics (PK) and pharmacodynamics (PD) characteristics of SPH3127 dose escalation, a single oral dose in Chines healthy volunteers.
2. To explore the appropriate dose and provide the basis for the subsequent clinical trials.
Trial arms
Trial start
2016-12-01
Estimated PCD
2018-06-30
Trial end
2018-07-30
Status
Completed
Phase
Early phase I
Treatment
SPH3127
Drug: SPH3127 Tablet
Drug: Placebo Tablet
Arms:
100 mg SPH3127 tablet-Dose 3, 200 mg SPH3127 tablet-Dose 4, 25 mg SPH3127 tablet-Dose 1, 400 mg SPH3127 tablet-Dose 5, 50 mg SPH3127 tablet-Dose 2, 800 mg SPH3127 tablet-Dose 6
Size
48
Primary endpoint
Assessment of safety parameters [adverse events, laboratory data, vital signs, and ECG]
10 days
Eligibility criteria
Inclusion Criteria:
* Healthy adults,age \>=18 years.Single gender should no less than a third of total subjects in each group.
* BMI should be18 to 24 kg/m2 (including threshold), allowing the lowest weight 50 kg (including threshold) for the male and 45 kg (including threshold) for the female.
* understand details of significance, benefit, inconvenience and potential danger of the research program, voluntarily signed informed consent.
Exclusion Criteria:
* during pregnancy, nursing mothers, and plans to test in the first 6 months (grant) pregnant;
* abnormal results in physical examination, laboratory examination and have clinical significance (such as: liver function examination - aspartate aminotransferase (AST)/alanine aminotransferase (ALT) is more than 1.5 times of the upper limit of normal).
* with cardiovascular, liver, kidney, gastrointestinal, nervous system, blood system and familial blood disease, thyroid dysfunction or abnormal mental illness;
* has a history of drug allergy and allergic constitution;
* took birth control pills within 6 weeks;
* used any drugs (including Chinese herbal medicine) within 1 week;
* participated in blood donation within 2 months ;
* participated in any drug clinical trials (as subjects) within three months;
* any positive result in virus serology check: human immunodeficiency virus antigen antibody (HIV Ag/Ab) 、hepatitis c virus (HCV) - IgG antibody to IgG, hepatitis b surface antigen (HBsAg) and treponema pallidum antibody (TP);
* addicted to cigarettes, alcohol, drink coffee, strong tea and drug abuse;
* researchers think that exists any unfavorable factors to participate in the test.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 48, 'type': 'ACTUAL'}}
Updated at
2022-10-27
1 organization
1 product
1 indication
Organization
Shanghai Pharmaceuticals HoldingProduct
SPH3127Indication
Hypertension