Assessment of Analgesic Effect of Ketamine Vs Ketamine Magnesium Infusion and Their Effect on Postoperative Morphine Consumption After Surgical Nephrectomy

Nirvana Ahmed 02

Ketamine and magnesium-ketamine are two analgesics that are being studied for use as adjuvants. They were shown to have anaesthetic and analgesic properties, and as a consequence of this finding, it has been postulated that they may have a role in minimising the requirement for analgesic drugs during the postoperative period. The major objective of the research was to examine the pain-relieving effects of ketamine vs ketamine magnesium infusion, as well as their influence on postoperative morphine consumption following nephrectomy; the secondary goal is to assess hemodynamic effects and pain severity.

2021-09-01

2022-05-01

2022-05-15

Completed

Early phase I

100

Inclusion Criteria: * Patients with elective nephrectomy Exclusion Criteria: * Pregnant women * Cases with severe chronic disease as liver cell failures, CHF * cases with allergies to ketamine and magnesium sulphate * cases with a history of current regular use of (analgesic, anticonvulsant, antidepressant) * chronic pain. * mental illness.

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 100, 'type': 'ACTUAL'}}

2022-10-27