Clinical trial
A Phase 1b Study of Duvelisib Administered in Combination With Obinutuzumab in Patients With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor (BTKi) (SYNCHRONY)
Name
IPI-145-18
Description
To evaluate the safety, pharmacokinetics, and pharmacodynamics of Duvelisib (IPI-145) in combination with obinutuzumab in patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma previously treated with a BTKi.
Trial arms
Trial start
2015-02-01
Estimated PCD
2016-11-01
Trial end
2016-11-01
Status
Terminated
Phase
Early phase I
Treatment
IPI-145 (duvelisib)
25mg and/or 5mg oral capsule
Arms:
IPI-145 in Combination with Obinutuzumab
Other names:
Duvelisib
Obinutuzumab
1000mg/40mL single-use vials
Arms:
IPI-145 in Combination with Obinutuzumab
Other names:
GAZYVA
Size
3
Primary endpoint
Dose-limiting toxicities (DLTs)
28 days
Treatment-emergent adverse events (TEAEs)
Up to 30 days from last dose of study treatment
Eligibility criteria
Inclusion Criteria:
* ≥18 years of age
* Diagnosis of Chronic lymphocytic leukemia or Small lymphocytic lymphoma that meets at least one of the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) 2008 criteria for treatment (Binet Stage ≥ B and/or Rai Stage ≥ I with symptoms)
* Measurable disease with a lymph node or tumor mass \>1.5 cm in at least one dimension as assessed by computed tomography (CT)
* Previous exposure to BTKi therapy and meets at least one of the below criteria:
* Progressive disease while receiving a BTKi therapy, or stable disease as best response after 12 months of receiving a BTKi therapy
* Discontinued a BTKi therapy due to BTKi treatment-related intolerance
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 (corresponds to Karnofsky Performance Status \[KPS\] ≥60%)
* Subjects must be able to receive outpatient treatment and laboratory monitoring (where specifically indicated) at the institution that administers study drug for the entire treatment period
Exclusion Criteria:
* Richter's transformation or prolymphocytic leukemia
* Refractory to obinutuzumab (defined as progression or relapse \<12 months of receiving obinutuzumab monotherapy or \<24 months of receiving an obinutuzumab-containing regimen)
* Progressive disease while previously receiving a PI3K inhibitor (e.g. GS-1101 \[idelalisib\], duvelisib) or a serious/severe AE related to PI3K inhibitor treatment
* History of severe reaction to prior monoclonal antibody therapy (defined as a Grade 4 event and/or requiring permanent discontinuation)
* Human immunodeficiency virus (HIV) or Human T Cell Lymphotropic Virus 1 (HTLV-1) infection
* Prior, current, or chronic hepatitis B or hepatitis C infection
* History of tuberculosis treatment within the preceding 2 years
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 3, 'type': 'ACTUAL'}}
Updated at
2023-02-27
1 organization
2 products
4 indications
Organization
SecuraBioProduct
IPI-145Indication
Lymphocytic LeukemiaIndication
ChronicIndication
lymphomaIndication
Small LymphocyticProduct
Obinutuzumab