Clinical trial
A Phase I/II, Randomized, Double-Masked, Vehicle-Controlled Study of the Safety, Tolerability, and Efficacy of AXR-270 Topical Eyelid Cream in Treating Posterior Blepharitis Associated With Meibomian Gland Dysfunction
Name
AXR201901
Description
This study will evaluate the safety, tolerability and efficacy of AXR-270 Cream in treating posterior blepharitis associated with Meibomian Gland Disease (MGD)
Trial arms
Trial start
2020-06-16
Estimated PCD
2020-12-01
Trial end
2020-12-31
Status
Completed
Phase
Early phase I
Treatment
AXR-270 Low Dose
AXR-270 Topical Eyelid Cream
Arms:
AXR-270 Low Dose
AXR-270 High Dose
AXR-270 Topical Eyelid Cream
Arms:
AXR-270 High Dose
AXR-270 Vehicle
AXR-270 Topical Eyelid Cream Vehicle
Arms:
AXR-270 Vehicle
Size
129
Primary endpoint
Adverse Events
22 Days
Eligibility criteria
Inclusion Criteria:
Male or female, 18 years or older
Have a clinical diagnosis of moderate to severe MGD (total MGD score between 5 and 14 on a scale with a range between 0 and 15; and clinical severity score of eyelid margin vascularity of at least 2 (moderate))
Have a score of ≥35 on Eye Discomfort using VAS
Have a tFCS score between 3 and 14 on the NEI scale
Have a Schirmer score of \>7 mm
Have a OSDI score \>30
If female, then subject should be non-pregnant and non-lactating
Exclusion Criteria:
Subjects with iritis, uveitis in either eye
Subjects with conjunctivitis, keratitis, severe anterior keratitis not related to MGD
Subjects with lid abnormalities
Subjects with ocular fungal, viral or bacterial infection
Subjects unable or unwilling to withhold the use of eyelid scrubs
Subjects with glaucoma and serious systemic disease
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 129, 'type': 'ACTUAL'}}
Updated at
2023-07-21
1 organization
1 product
2 indications
Organization
AxeroVisionProduct
AXR-270Indication
BlepharitisIndication
Meibomian Gland Dysfunction