Clinical trial
A Phase 2, Open-Label Trial to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Exploratory Clinical Activity of ALN-TTRSC in Patients With Transthyretin (TTR) Cardiac Amyloidosis
Name
ALN-TTRSC-002
Description
The purpose of this study is to determine the pharmacokinetics, pharmacodynamics and exploratory clinical activity of ALN-TTRSC (revusiran) in Patients with Transthyretin (TTR) Cardiac Amyloidosis.
Trial arms
Trial start
2013-12-01
Estimated PCD
2014-10-01
Trial end
2015-01-01
Status
Completed
Phase
Early phase I
Treatment
ALN-TTRSC (revusiran) for subcutaneous administration
Arms:
ALN-TTRSC (revusiran)
Size
26
Primary endpoint
The proportion of subjects experiencing adverse events (AEs), serious adverse events (SAEs) and study drug discontinuation.
Up to 63 days
Eligibility criteria
Inclusion Criteria:
* TTR cardiac amyloidosis;
* Women of child-bearing potential (WOCBP) must have a negative pregnancy test, cannot be breast feeding, and must be willing to use 2 highly effective methods of contraception;
* Male subjects agree to use appropriate contraception;
* Adequate blood counts, liver, renal and heart function;
* Adequate Karnofsky performance status;
* Adequate New York Heart Association (NYHA) Classification Score;
* Clinically stable on heart medications;
* Adequate 6-minute walk test;
* Willing to give written informed consent and are willing to comply with the study requirements.
Exclusion Criteria:
* Known human immunodeficiency virus (HIV) positive status or known or suspected systemic bacterial, viral, parasitic, or fungal infection;
* Subjects with a history of multiple drug allergies or intolerance to SC injection;
* Received an investigational agent other than tafamidis, diflunisal, doxycycline or tauroursodeoxycholic acid, or an investigational device within 30 days prior to first dose of study;
* Uncontrolled hypertension, ischemic heart disease or cardiac arrhythmia;
* Untreated hypo- or hyperthyroidism;
* Prior major organ transplant;
* Considered unfit for the study by the Principal Investigator.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 26, 'type': 'ACTUAL'}}
Updated at
2023-03-20
1 organization
1 product
1 indication
Product
ALN-TTRSCIndication
TTR-mediated AmyloidosisOrganization
Alnylam Pharmaceuticals