Clinical trial
An International, Phase 3, Open-Label, Randomized Study of BGB-3111 Compared With Bendamustine Plus Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (CLL/SLL)
Name
BGB-3111-304
Description
To compare efficacy between zanubrutinib versus bendamustine and rituximab in patients with previously untreated CLL/SLL, as measured by progression free survival assess by Independent Central Review.
Trial arms
Trial start
2017-10-31
Estimated PCD
2021-05-07
Trial end
2026-09-01
Status
Active (not recruiting)
Phase
Early phase I
Treatment
Zanubrutinib
Administered as two 80-milligram (mg) capsules by mouth twice a day (160 mg twice a day)
Arms:
Cohort 1: Zanubrutinib, Cohort 1a (China only): Zanubrutinib, Cohort 2: Zanubrutinib, Cohort 3: Venetoclax + Zanubrutinib
Other names:
BGB-3111, BRUKINSA
Bendamustine
Administered intravenously (IV) at a dose of 90 mg/m\^2/day on the first 2 days of each cycle for 6 cycles.
Arms:
Cohort 1: Bendamustine + Rituximab, Cohort 1a (China only): Bendamustine + Rituximab
Other names:
Treanda, Ribomustin, and Levact
Rituximab
Administered intravenously (IV) at a dose of 375 mg/m\^2 on day 0 of cycle 1, and at a dose of 500 mg/m\^2 on day 1 of cycles 2 to 6
Arms:
Cohort 1: Bendamustine + Rituximab, Cohort 1a (China only): Bendamustine + Rituximab
Other names:
Rituxan, MabThera
Venetoclax
400 mg tablets administered orally once daily.
Arms:
Cohort 3: Venetoclax + Zanubrutinib
Other names:
Venclexta, Venclyxto
Size
590
Primary endpoint
Cohort 1: Progression-free Survival (PFS) as Determined by Independent Central Review (ICR)
Up to approximately 3 years and 7 months (as of cut-off date of 07MAY2021)
Eligibility criteria
Key Inclusion Criteria:
* Unsuitable for chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab (FCR)
* Confirmed diagnosis of CD20-positive CLL or SLL, requiring treatment
* Measurable disease by imaging
* Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
* Life expectancy ≥ 6 months
* Adequate bone marrow function
* Adequate renal and hepatic function
Key Exclusion Criteria:
* Previous systemic treatment for CLL/SLL
* Requires ongoing need for corticosteroid treatment
* Known prolymphocytic leukemia or history of or suspected Richter's transformation.
* Clinically significant cardiovascular disease
* Prior malignancy within the past 3 years, except for curatively treated basal or squamous cell skin cancer, non-muscle-invasive bladder cancer, carcinoma in situ of the cervix of breast, or localized Gleason score 6 prostate cancer
* History of severe bleeding disorder
* History of stroke or intracranial hemorrhage within 6 months before the first dose of study drug
* Severe or debilitating pulmonary disease
* Inability to swallow capsules or disease affecting gastrointestinal function
* Active infection requiring systemic treatment
* Known central nervous system involvement by leukemia or lymphoma
* Underlying medical condition that will render the administration of study drug hazardous or obscure interpretation of toxicity or AEs
* Known infection with human immunodeficiency virus (HIV) or active hepatitis B or C infection
* Major surgery ≤ 4 weeks prior to start of study treatment
* Pregnant or nursing females
* Vaccination with live vaccine within 35 days prior to the first dose of study drug.
* Ongoing alcohol or drug addiction
* Known hypersensitivity to zanubrutinib, bendamustine, rituximab, or venetoclax (as applicable) or any other ingredients of the study drugs
* Requires ongoing treatment with strong cytochrome P450 (CYP3A) inhibitor or inducer
* Concurrent participation in another therapeutic clinical study
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 590, 'type': 'ACTUAL'}}
Updated at
2023-11-09
1 organization
4 products
2 indications
Organization
BeiGeneProduct
ZanubrutinibIndication
Chronic Lymphocytic LeukemiaIndication
Small Lymphocytic LymphomaProduct
BendamustineProduct
RituximabProduct
Venetoclax