Clinical trial
A Phase 1 Randomized, Double-Blinded, Active-Controlled, 2-Dose Study to Assess the Safety and Immunogenicity of a Herpes Zoster (HZ) Vaccine, JCXH-105, in Healthy Subjects 50 to 69 Years of Age.
Name
JCXH-105-001
Description
The goal of this clinical trial is to assess the safety and immunogenicity of a self-replicating (sr) RNA-based vaccine, JCXH-105, in the prevention of Shingles (Herpes Zoster)
Participant will be randomized to receive either JCXH-105 or Shingrix.
Trial arms
Trial start
2023-05-26
Estimated PCD
2024-02-23
Trial end
2024-03-21
Status
Active (not recruiting)
Phase
Early phase I
Treatment
JCXH-105
As IM injection
Arms:
Investigational Product
Active Control (Shingrix)
As IM injection
Arms:
Active Control
Size
75
Primary endpoint
SAE Frequency
Day 1 - Day 241
Injection site reaction
7 days after the first and second vaccination
Solicited systemic reaction frequency
7 days after the first and second vaccination
AE frequency
30 days after the first and second vaccination
Medically attended AE frequency
Day 1 - Day 241
The frequency of potential immune-mediated adverse events"
Day 1 - Day 241
Eligibility criteria
Inclusion Criteria:
* Sex: Male or female; female subjects may be of childbearing potential, of nonchildbearing potential, or postmenopausal.
* Age: 50 to 69 years of age, inclusive, at screening.
* Status: Healthy subjects. Note: Healthy status as defined by the absence of evidence of any clinically significant active or chronic disease, in the opinion of the Investigator, following a detailed medical and surgical history, a complete physical examination including vital signs, 12-lead electrocardiogram (ECG) recording, hematology, blood chemistry, serology, and urinalysis. Healthy subjects may have stable pre-existing disease defined as disease not requiring significant change in therapy or hospitalization for worsening disease during the 6 weeks prior to enrollment.
* Subjects must agree to not be vaccinated with any HZ vaccine while participating in this study.
* All values for hematology and clinical chemistry tests of blood and urine within the normal range OR showing no clinically relevant deviations based on medical history, considering stable pre-existing diseases (see Healthy Subjects above), as judged by the Investigator.
Exclusion Criteria:
* Subjects with a history of HZ or current diagnosis of shingles.
* Previous vaccination against HZ.
* Subjects with any respiratory illness deemed clinically relevant by the Investigator within the past month OR hospitalization \>24 hours for any reason within the past month prior to the first vaccine administration (JCXH-105 or Shingrix).
* Subjects with history of myocarditis or pericarditis, or with AEs after mRNA vaccination that are in nature and severity beyond the common expected AEs necessitating medical intervention.
* Subjects who have received an mRNA-based vaccine (e.g., Spikevax, Comirnaty, etc.) 30 days prior to Day 1.
* Subjects who received any non-live vaccine within 14 days prior to the first vaccine administration (JCXH-105 or Shingrix).
* Subjects who received within 28 days prior to first vaccine administration (JCXH-105 or Shingrix): (1) Any live vaccine, (2) Immunomodulators or immune-suppressive medication, (3) Granulocyte-macrophage colony-stimulating factor, (4) Three or more consecutive days of systemic corticosteroids. Note: subjects on stable-dose steroid replacement (for chronic disease such as iatrogenic deficiency) of prednisone ≤10 mg/day or equivalent are allowed, and (5) Other investigational agents or devices.
* Subjects with active or suspected immunosuppression, immunodeficiency, or autoimmune disease.
* Subjects receiving systemic antiviral therapy.
* Subjects with a positive screening test for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibodies, or anti-human HIV-1 and 2 antibodies.
* Subjects with a positive screening test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
* Subjects with a known history of active or latent tuberculosis (bacillus tuberculosis).
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'maskingDescription': 'Double blinded study', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 75, 'type': 'ESTIMATED'}}
Updated at
2023-11-18
1 organization
2 products
3 indications
Product
JCXH-105Indication
Herpes ZosterIndication
Herpes zosterIndication
Infectious DiseaseOrganization
Immorna BiotherapeuticsProduct
Active Control