Clinical trial
A Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of UBITh® PD Immunotherapeutic Vaccine (UB-312) in Healthy Participants and Participants With Parkinson's Disease
Name
UB-312-101
Description
This is a 44-week, randomized, placebo-controlled, double-blind, single-center, phase 1 clinical trial consisting of a dose-escalation Part A study in healthy participants, followed by a Part B in participants with Parkinson's disease with a selected doses from Part A.
Trial arms
Trial start
2019-08-29
Estimated PCD
2023-03-01
Trial end
2023-03-01
Status
Completed
Phase
Early phase I
Treatment
UB-312
A synthetic peptide-based vaccine
Arms:
UB-312 100 mcg, UB-312 1000 mcg, UB-312 2000 mcg, UB-312 300 mcg, UB-312 300/100 mcg, UB-312 40 mcg, UB-312 40/1000 mcg, UB-312 40/300 mcg
Placebo
Matching placebo
Arms:
Placebo
Size
70
Primary endpoint
Frequency of Adverse Events
44 weeks
Immunogenicity of UB-312 as determined by anti-aSyn antibodies in blood and CSF
Weeks 1, 2, 5, 6, 9, 13, 14, 17, 21, 29, 37 and 45
Immunogenicity of UB-312 as determined by anti-aSyn antibodies in blood and CSF
Weeks 1, 21 and 45
Eligibility criteria
Inclusion Criteria:
* Male or female aged 40 to 85 years old, inclusive at screening
* Expected to be able to undergo all study procedures
* Other inclusion criteria apply
For Part B only:
* A diagnosis of PD, confirmed by a neurologist
* Hoehn \&Yahr Stage ≤ III at Screening
* Stable treatment of permitted antiparkinsonian medications from 30 days prior to first study drug administration or 60 days for MAO-B inhibitors, and expected to remain stable throughout the study
Exclusion Criteria:
* Clinically significant abnormalities, as judged by the investigator
* History of medical, neurological or psychiatric conditions which in the opinion of the investigator may compromise participant's safety or scientific value of the study
* Acute or chronic infection as judged by the investigator, for positive human immunodeficiency virus (HIV), hepatitis C virus (HCV) or hepatitis B virus (HBV)
* History or evidence of an autoimmune disorder
* History of anergy.
* Participated/participating in any clinical trial with monoclonal antibodies or vaccines directed at aSyn
* Other exclusion criteria apply
For Part B only:
* Other known or suspected cause of Parkinsonism other than idiopathic PD
* History or evidence at Screening of PD-related freezing episodes, falls, or orthostatic hypotension
* Dopamine transporter single-photon emission computerized tomography scan (DaTscan) inconsistent with dopamine transporter deficit.
* Clinically significant neurological disease other than PD
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 70, 'type': 'ACTUAL'}}
Updated at
2023-12-05
1 organization
2 products
2 indications
Product
UB-312Indication
Parkinson's DiseaseIndication
Parkinson's diseaseOrganization
United NeuroscienceProduct
Placebo