Clinical trial
A Phase 1/2 Multiple Expansion Cohort Trial of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation
Name
1133-001
Description
A Phase 1/2 study of MRTX1133 in solid tumors harboring a KRAS G12D mutation.
Trial arms
Trial start
2023-03-20
Estimated PCD
2026-08-30
Trial end
2026-08-30
Status
Recruiting
Phase
Early phase I
Treatment
MRTX1133
KRAS G12D Inhibitor
Arms:
Phase 1/1B, Phase 2
Size
386
Primary endpoint
Phase 1: Number of Patients who Experience Dose-Limiting Toxicity
21 Days
Phase 1/1b: Number of patients who experience a treatment-related adverse event
Up to 2 years
Phase 2: Objective response rate (ORR)
2 years
Phase 2: Duration of response (DOR)
2 years
Phase 2: Progression free survival (PFS)
2 years
Phase 2: Overall survival (OS)
2 years
Eligibility criteria
Inclusion Criteria:
* Histologically confirmed diagnosis of a solid tumor malignancy harboring KRAS G12D mutation in tumor tissue or ctDNA.
* Unresectable or metastatic disease.
* Patients must have received standard therapies appropriate for their tumor type and stage; first-line treatment for PDAC for certain cohorts.
* Presence of tumor lesions to be evaluated per RECIST v1.1:
1. in the Phase 1 dose escalation cohorts, patients must have measurable or evaluable disease.
2. in the Phase 1b and Phase 2 cohorts, patients must have measurable disease.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Adequate organ function.
* Age ≥ 18 years
Exclusion Criteria:
* Active brain metastases or carcinomatous meningitis.
* Prior treatment with a KRAS G12D inhibitor (Phase 1b \& Phase 2 only).
* History of significant hemoptysis or hemorrhage within 4 weeks of the first dose of study treatment.
* History of intestinal disease, inflammatory bowel disease, major gastric surgery, or other gastrointestinal conditions likely to alter absorption of study treatment or result in inability to swallow oral medications.
* History of malignant small bowel obstruction.
* Cardiac abnormalities.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1', 'PHASE2'], 'designInfo': {'allocation': 'NON_RANDOMIZED', 'interventionModel': 'SEQUENTIAL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 386, 'type': 'ESTIMATED'}}
Updated at
2023-11-21
1 organization
1 product
5 indications
Organization
Mirati TherapeuticsProduct
MRTX1133Indication
Solid TumorIndication
Advanced Solid TumorIndication
Lung CancerIndication
Colorectal CancerIndication
Pancreatic adenocarcinoma