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Clinical trial

The Cost-effectiveness Analysis of Immunosuppressants to Postoperative Infection and Death in the Patients With Organ Transplantation

ID
Name
CS2-21134
Description
The goal of this observational study is to explore the different immunosuppressive agents and related outcomes in organ transplantation patients in Taiwan. The main question it aims to answer is the risk of different immunosuppressive agents for infection and survival after transplant. The study enrolled patients who underwent solid organ transplant (SOT), kidney (ICD-9-CM code V42.0), liver (ICD-9-CM code V42.7), or lung (ICD-9-CM code V42.6) transplants. We employed propensity score matching (PSM) to establish a matched cohort. The study will compare SOT patients and general patients to explore the risk of different immunosuppressive agents for infection and survival.
Trial arms
Trial start
2021-12-20
Estimated PCD
2024-11-20
Trial end
2024-12-20
Status
Recruiting
Treatment
Immunosuppressive Agents
Prescribing immunosuppressive agents
Arms:
Patients with organ transplantation, Patients without organ transplantation
Size
20000
Primary endpoint
Postoperative infection
From the date of underwent SOTs until the date of incident infection or date of death from any cause, whichever came first, assessed up to 5 years.
Death
From the date of underwent SOTs until the date of death from any cause, assessed up to 5 years.
Eligibility criteria
Inclusion Criteria: * Patients who underwent solid organ transplant (SOT) Exclusion Criteria: * Patients who received more than one SOT, had an infectious disease diagnosis before their SOT or had incomplete medical information in the database.
Protocol
{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'RETROSPECTIVE'}, 'enrollmentInfo': {'count': 20000, 'type': 'ESTIMATED'}}
Updated at
2023-11-08

1 organization

1 product

3 indications

Organization
Chung Shan Medical University
Product
Immunosuppressive Agents
Indication
Organ Transplantation
Indication
Immunosuppressive Agents
Indication
Cohort Study