Clinical trial
Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
Name
834482
Description
This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a mixed meal, and higher levels of intact DPP4 substrates compared to during placebo and compared to matched controls.
Trial arms
Trial start
2020-08-26
Estimated PCD
2024-03-31
Trial end
2024-12-31
Status
Recruiting
Phase
Early phase I
Treatment
Sitagliptin 100mg
Sitagliptin will be administered daily for 7 days, with a study day on day 7.
Arms:
Crossover AB, Crossover BA
Other names:
Januvia
Placebo Oral Tablet
Placebo will be administered daily for 7 days, with a study day on day 7.
Arms:
Crossover AB, Crossover BA
Size
20
Primary endpoint
Dipeptidyl peptidase 4 (DPP4)
during study days 1 and 2
Eligibility criteria
Inclusion Criteria:
* Participant of the Penn Medicine Biobank who is willing to be recontacted to participate in future research.
* Cases are defined as adults 18-70 years with likely decreased DPP4.
* Controls are defined as adults who are matched to cases by: age, gender, race, BMI, hypertension status, diabetes status, renal function, and medication use that may affect outcomes of interest.
Exclusion Criteria:
* The study will exclude volunteers with any significant medical conditions that may interfere with study participation, data interpretation, or pose safety risk(s) to the subject.
* Recent hospitalization or acute illness such as infection within the past two weeks
* Pregnancy
* Use of insulin
* Use of a GLP-1 agonist or DPP4 inhibitor medication
* Use of oral diabetes agents other than metformin unless matched with controls
* Type 1 diabetes
* Chronic steroid use or use within the last 30 days
* Significant liver disease including liver enzymes \>3 x upper limit of normal range
* Renal dysfunction defined as eGFR\< 50mL/min/1.73m2
* Significant cardiac disease such as heart transplantation
* Significant gastrointestinal conditions that may interfere with drug absorption or GLP-1 release including bariatric surgery
* Significant hematologic disease such as hematocrit \<35%
* Use of chronic anticoagulation
* Severe pulmonary disease
* Severe neurologic or psychiatric disease
* Inability to comprehend study procedures
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'CROSSOVER', 'interventionModelDescription': 'blinded 2:2 crossover, placebo-controlled', 'primaryPurpose': 'OTHER', 'maskingInfo': {'masking': 'QUADRUPLE', 'maskingDescription': 'Neither subjects, nor the investigator or key study personnel will know drug randomization until after data analyses are completed.', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 20, 'type': 'ESTIMATED'}}
Updated at
2023-10-27
1 organization
2 products
3 indications
Organization
University of PennsylvaniaProduct
SitagliptinIndication
Genetic DiseaseIndication
Type 2 DiabetesIndication
Congestive Heart FailureProduct
Placebo