Clinical trial
A Multi-center Randomized Phase II Study Comparing Corticosteroids Alone Versus Corticosteroids and Extracorporeal Photopheresis as First-line Treatment of Grade II Acute Graft-versus-host Disease With Skin Involvement Occuring After Allogeneic Stem Cell Transplantation
Name
2023-508614-41-00
Description
The goal of this clinical trial is to compare as a first line of grade II skin acute GVHD sconventional treatment with steroids alone to a combination of steroids and extracoporeal photopheresis (ECP)
The primary end point will compare Freedom from treatment failure at 6 months from randomization as defined by meeting all the following 4 conditions:
* to be alive
* without relapse of the hematological disease
* without having required a new line of treatment for acute GVHD
* without initiating a systemic treatment for chronic GVHD.
Trial arms
Trial start
2024-01-01
Estimated PCD
2025-09-01
Trial end
2026-01-01
Status
Not yet recruiting
Phase
Early phase I
Treatment
Uvadex
Uvadex use for ECP
Arms:
ECP + steroids
Steroids
steroids 2 mg/kg/d
Arms:
Steroids alone
Size
42
Primary endpoint
Freedom from treatment failure
at 6 months from randomization
Eligibility criteria
Inclusion Criteria:
* Age \> 18 years,
* allogeneic hematopoietic stem cell transplantation received (from any type of graft and donor) after malignant or non malignant disease
* patient suffering from Grade II acute GVHD with skin +/- high GI involvement (stage 2-3 skin + upper gastrointestinal tract or skin stage 3) in the 3 months following stem cell transplantation
* patient requiring first line treatment for acute GVHD
* patient able to start PCE therapy in the 3 days after randomization
* validation of the presence of a peripheral or central venous access (its type should be conform to the recommendations described in the Therakos Cellex operator manual), allowing to perform PCE sessions weekly during 3 months. In the absence of appropriate preexisting central line at inclusion, peripheral access will be preferred.
* leukocytes \> 1.5 G/l, platelets \> 30 G/l, hematocrit \> 27% (blood transfusion are permitted), based on the last available blood testing results,
* patient with French Health Insurance,
* patient informed about the clinical trial content and organization,
* informed consent form signed.
Exclusion Criteria:
* - Grade 1 acute GVHD,
* acute GVH grade \> II or acute GVH with lower gastrointestinal tract or with liver involvement,
* relapse of the hematologic disease at time of acute GVHD,
* uncontrolled ongoing infection at time of inclusion: bacterial or fungal infections, CMV reactivation with increasing CMV viral load,
* HIV positivity or replicative HBV or HCV infection (based on pre-transplant assessment),
* patient with allergy or contraindications to UVADEX, extracorporeal photopheresis, steroids, or posaconazole (see details in the study protocol),
* woman of childbearing age without efficient contraceptive method, pregnancy or breast feeding woman,
* patient with history of profound venous thrombosis in the last 5 years,
* patient included in another acute GVHD prospective clinical trial.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 42, 'type': 'ESTIMATED'}}
Updated at
2023-11-15
1 organization
2 products
1 indication
Organization
Central HospitalProduct
UvadexIndication
Graft-Vs-Host DiseaseProduct
Steroids