Clinical trial
"Effect of Tadalafil, Sildenafil and Pentoxyfylline on Endometrial Thickness and Frozen Embryo Transfer Outcomes
Name
Tadalafil IVF
Description
The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated
Trial arms
Trial start
2023-07-30
Estimated PCD
2023-10-30
Trial end
2023-10-30
Status
Not yet recruiting
Phase
Early phase I
Treatment
tadalafil
tadalafil 10 mg one tablet daily
Arms:
tadalafil
Other names:
cialong
Sildenafil
sildenafil 20 mg two tablets daily
Arms:
sildenafil
Other names:
Respatio
pentoxifylline
pentoxifylline 400 mg two tabs daily
Arms:
pentoxifylline
Other names:
trental
Size
200
Primary endpoint
endometrial thickness
within 16 day of menstruation
Eligibility criteria
Inclusion Criteria:
* women having thawed embryos
Exclusion Criteria:
* hypotension
* cardiovascular, hepatic, and renal diseases;
* uncontrolled diabetes mellitus;
* ovarian cysts;
* hyperprolactinemia;
* abnormal thyroid functions;
* uterine fibroids;
* patients taking nitrates;
* endometriosis and adenomyosis
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2', 'PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 200, 'type': 'ESTIMATED'}}
Updated at
2023-08-03
1 organization
2 products
1 drug
1 indication
Organization
Beni-Suef UniversityDrug
tadalafilIndication
In vitro fertilization (IVF)Product
SildenafilProduct
pentoxifylline