Clinical trial
Double-blinded, Placebo-controlled, Munticenter, Phase IIa Clinical Trial of Hepalatide in Patients With Chronic Hepatitis D
Name
L47-HD-IIa
Description
A phase 2a clinical Study of Hepalatide for Injection in Subjects with Chronic Hepatitis D
Trial arms
Trial start
2023-10-07
Estimated PCD
2024-01-30
Trial end
2024-02-01
Status
Completed
Phase
Early phase I
Treatment
Hepalatide
Either the placebo or hepalatide (2.1 mg, 4.2 mg, or 6.3 mg) will be given for 4 consecutive weeks. s.c., once daily.
Arms:
Hepalatide 2.1mg, Hepalatide 4.2mg, Hepalatide 6.3mg
Other names:
L47
Hepalatide Placebo
Either the placebo or hepalatide (2.1 mg, 4.2 mg, or 6.3 mg) will be given for 4 consecutive weeks. s.c., once daily.
Arms:
Placebo 2.1mg/4.2mg/6.3mg
Other names:
Placebo
Size
23
Primary endpoint
Hepatitis D Virus(HDV) RNA level
Week 4
Eligibility criteria
Inclusion Criteria:
* Male or female, 18-65 years old (both inclusive);
* HBsAg (+) and/or HBV DNA (+) for at least 6 months (clinically diagnosed as "chronic hepatitis B");
* HDV-antibody (IgG/IgM) (+) and HDV RNA (+);
* 1×ULN \<ALT\<10×ULN;
* Patients with hepatitis B eligible to receive treatment with NAs according to current guidelines for the diagnosis and treatment of hepatitis B;
* Patients who do not plan a pregnancy within two years (women who are not pregnant or lactating) and agree to take effective contraceptive measures throughout the treatment period and within 3 months after the last dose;
* Patients who did not participate in any other clinical trials within 3 months;
* Patients with good compliance with the study protocol;
* Patients who understand and agree to sign an informed consent form.
Exclusion Criteria:
* Decompensated liver disease: Direct bilirubin \> 1.2× ULN, prothrombin time \> 1.2× ULN, and serum albumin \< 35 g/L;
* Patients with abnormal results of routine hematology test: White blood cell count (WBC) \< 3×109/L, neutrophil count \< 1.5×109/L and platelet count \< 60×109/L;
* Severely decompensated hepatic fiborosis or decompensated cirrhosis: Definitely diagnosed decompensated cirrhosis by imaging examinations such as a Color Doppler ultrasound and CT of the abdomen or clinically diagnosed decompensated cirrhosis by the investigator, or a Metavir fibrosis score of 4 on a liver biopsy sample, or a Child-Pugh score \> 7 for liver function assessment;
* Patients who have any of the following conditions:
1. A history of decompensated liver disease (ascites, jaundice, hepatic encephalopathy, variceal bleeding);
2. A history of serious cardiovascular disease (including unstable or uncontrolled cardiovascular disease within 6 months);
3. Serious mental illness or a history of serious mental illness;
4. A history of organ transplantation;
5. Uncontrolled epilepsy, mental illness, or poorly controlled diabetes or hypertension;
6. Autoimmune disease, immune-related extrahepatic manifestations (vasculitis, purpura, arteritis nodosa, peripheral neuropathy, and glomerulonephritis), thyroid disease, malignant tumor, and receiving immunosuppressive therapy;
7. Underlying diseases such as severe infection, heart failure, chronic obstructive pulmonary disease, and other severe diseases;
8. A history of alcohol or drug abuse.
* Creatinine clearance \< 60 mL/min;
* HAV/HCV/HEV/HIV co-infection;
* Resistance to or poor response to Entecavir;
* An allergic reaction to Entecavir;
* Patients who have used interferon within 3 months before the screening period;
* Previously received L47 or Bulevirtide;
* Women who have a positive pregnancy test;
* Patients who have other significantly abnormal results of laboratory or auxiliary tests and are unsuitable for this trial.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 23, 'type': 'ACTUAL'}}
Updated at
2024-04-24
1 organization
1 product
1 indication
Organization
Shanghai HEP PharmaceuticalProduct
HepalatideIndication
Hepatitis D