Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms

134-2015

In this study, potential associations between several genetic polymorphisms and nicotine dependence will be examined. The relative reinforcing efficacy of cigarettes using the forced-choice procedure will be assessed. In addition, reactivity to smoking cues using a reliable procedure will be conducted.

2016-08-01

2019-11-29

2019-11-29

Completed

26

Inclusion Criteria: 1. 19-64 year old males and females 2. smoking at least 10 cigarettes per day for at least 1 year 3. positive urinary cotinine 4. medically and psychologically healthy as determined by screening criteria Exclusion Criteria: 1. definite plan to reduce or quit tobacco use during the course of the study 2. treatment for tobacco dependence in the past 3 months 3. use of nicotine replacement products, bupropion, or varenicline in the past 3 months 4. consumption of more than 15 alcoholic drinks per week during the past month 5. use of any illicit drug more than twice per week during the past month 6. current use of any medication that would interfere with the protocol in the opinion of PI 7. under the influence of a drug or alcohol at any session 8. pregnant, nursing, or become pregnant during the study

{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'OTHER', 'timePerspective': 'PROSPECTIVE'}, 'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Blood samples will be collected'}, 'enrollmentInfo': {'count': 26, 'type': 'ACTUAL'}}

2024-03-08