Clinical trial

Tetrandrine Tablets Used in Hospitalized Adults With COVID-19: a Double-blind, Placebo-controlled, Randomised Trial

Name
M2023002
Description
The primary objective of this study is to evaluate the effectiveness of tetrandrine tablets in preventing the progression of COVID-19 from severe to critical.
Trial arms
Trial start
2023-12-31
Estimated PCD
2025-12-12
Trial end
2025-12-12
Status
Not yet recruiting
Phase
Early phase I
Treatment
Tetrandrine
tetrandrine TID for 28 days
Arms:
placebo group, tetrandrine group
Size
414
Primary endpoint
Diagnosed with critical COVID-19 pneumonia
84 days
Eligibility criteria
Inclusion Criteria: 1. Sign informed consent form voluntarily for the trial. 2. Male or female aged between 18 and 85 years (inclusive). 3. Clinically or laboratory confirmed COVID-19 within the past 7 days, as determined by a positive RT-PCR test or a positive antigen test. 4. Under resting conditions, oxygen saturation ≤93% when breathing air, or P/F value ≤ 300 mmHg (1 mmHg = 0.133 kPa). 5. No birth plan and must agree to take effective contraceptive methods. Exclusion Criteria: 1. Received a vaccine within 4 weeks prior to the study, or plan to receive a vaccine during the study period, or received treatment with tetrandrine tables prior to enrolling in the study. 2. Patient must be on invasive mechanical ventilation/ECMO at baseline. 3. Any clinically important serious diseases unstable or uncontrolled. 4. Allergy history to any biological or other agent. 5. Patient has severe mental or psychological abnormalities, cognitive impairment or intellectual disability before being diagnosed with COVID-19. 6. Subjects who are pregnant or breastfeeding, or plan to become pregnant during the study. 7. Investigator think the subject should not participate in the study.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER']}}, 'enrollmentInfo': {'count': 414, 'type': 'ESTIMATED'}}
Updated at
2023-11-18

1 organization

1 product

1 indication

Indication
COVID-19