Clinical trial
Molecular Analysis of Intracanal Microbes After Chemomechanical Procedure and Root Canal Medication: Clinical Study
Name
Molecular Analysis
Description
This study aimed to evaluate clinically the intracanal microbes at molecular level after using established root canal medicament Calcium hydroxide and potential root canal medicament Glycyrrhizin.and Decontamination Analysis of Controls samples.
Trial arms
Trial start
2022-05-03
Estimated PCD
2023-12-20
Trial end
2024-01-15
Status
Completed
Phase
Early phase I
Treatment
Glycyrrhizin
used as intracanal medication for one week
Arms:
Group 1 (n = 10): Ca(OH)2, Group 2 (n = 10): Glycyrrhizin, Post disinfection (30% H2O2, followed by 2.5% NaOCl) NaOCl inactivated with 5% sodium thiosulfate., Pre disinfection (30% H2O2, followed by 2.5% NaOCl) NaOCl inactivated with 5% sodium thiosulfate.
Other names:
Calcium hydroxide
Size
20
Primary endpoint
minimizing of viable bacteria which showed by Real time PCR
after one week
Eligibility criteria
Inclusion Criteria:
Single-rooted teeth with a single canal, necrotic pulp (did not respond to sensitivity testing) and symptomatic apical periodontitis
* The age ranges from 19 to 60 years
Exclusion Criteria:- Receiving antibiotic treatment within the preceding 3 months.
* Reporting systemic disease.
* Teeth that could not be isolated with rubber dam.
* Teeth with periodontal pockets deeper than 3 mm.
* Root fracture or badly decayed teeth.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 20, 'type': 'ACTUAL'}}
Updated at
2024-03-04
1 organization
1 product
1 indication
Organization
Mansoura UniversityProduct
Glycyrrhizin