Clinical trial
Immune Response to the Recombinant Zoster Vaccine in People Living With HIV Over 50 Years of Age Compared to Non-HIV Age- and Gender-matched Controls - The Shingr'HIV Phase IV Multicenter Study
Name
2022-01314
Description
The purpose of this study is to evaluate the efficacy and safety of the adjuvanted recombinant Zoster vaccine (RZV, or Shingrix®) in older people (\> 50 years) living with HIV (PLWH) compared to age-matched healthy adults over a 1-year period.
Trial arms
Trial start
2022-12-14
Estimated PCD
2024-09-30
Trial end
2025-09-30
Status
Recruiting
Phase
Early phase I
Treatment
Recombinant Zoster Vaccine
Shingrix® vaccine will be administered in two vaccinations on Day0 and Day60
Arms:
RZV or Shingrix®)
Other names:
(Shingrix® )
Size
225
Primary endpoint
Geometric mean titer (GMT) of gE-specific total IgG
Day 90
Eligibility criteria
Inclusion Criteria:
For PLWH:
* Be registered in the SHCS or in the ANRS CO3 Aquitaine Cohort
* Age \>50 YOA
* Time since cART initiation \> 10 years
* Not already vaccinated with RZV
* HIV viral load \<50 copies/ml (within 6 months from the last blood sampling)
* Informed consent as documented by signature
* (France) : Person affiliated with or beneficiary of the French social security scheme
For aged/gender-matched controls
* Age \>50 YOA
* Not already vaccinated with RZV
* Informed consent as documented by signature
* (France) Not HIV infected
* (France) Person affiliated with or beneficiary of the French social security scheme
Exclusion Criteria:
* Ongoing signs of febrile or non-febrile infection at the time of the first vaccination
* Immunosuppression from the following:
* Current malignant neoplasm;
* primary immunodeficiency;
* recent (\<2 years) solid or bone-marrow transplant or any transplant still requiring immunosuppressive therapy
* Intake of drugs which suppress the immune system (e.g. glucocorticoids for a long time \[an equivalent dose of prednisolone \>20 mg/day \> 3 months\], monoclonal antibodies, cytostatics, biological products, etc.) within 6 months before screening.
* Administration of immunoglobulins or any blood products within 3 months preceding the first dose of vaccine or planned administration during the study period
* Having received a vaccine in the last month or is expected to receive a vaccine in the next month
* Having received a shingles vaccine within one year
* Presented with herpes zoster in the previous year
* Contra-indication to RZV
* Hospitalized patients
* Unable to provide informed consent or inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
* Participation in another study with investigational drug within the 30 days preceding and during the present study.
* (France) Pregnant or breastfeeding woman
* (France) Patient governed by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent)
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 225, 'type': 'ESTIMATED'}}
Updated at
2023-11-08
1 organization
1 product
1 indication
Organization
Calmy AlexandraProduct
Recombinant Zoster VaccineIndication
RZV Vaccine (Shingrix)