Clinical trial
Randomized Control Trial Comparison Between Intra-articular Infiltrations of PRP, MFAT, and PRP-MFAT in the Treatment of Symptomatic Knee Osteoarthritis.
Name
RCAPHM21_0431
Description
This research protocol evaluate the efficacity of intra-articular injections of autologous microfat associated with a preparation of autologous PRP, in symptomatic, resistant to first-line medical treatment, degenerative or post-traumatic cartilage lesions of the knee.
The primary objective of this study is to show the superiority of intra-articular injection of autologous microfat combined with autologous PRP preparation compared to injection of microfat or PRP used alone, on the KOOS score at 6 months.
Trial arms
Trial start
2024-02-02
Estimated PCD
2027-02-01
Trial end
2028-03-01
Status
Not yet recruiting
Phase
Early phase I
Treatment
Intra-articular injection of autologous microfat
A preparation of autologous microfat (5mL) will be injected intra-articularly.
Arms:
autologous microfat (MG)
Intra-articular injection of autologous platelet-rich plasma
A preparation of autologous platelet-rich plasma (5mL) will be injected intra-articularly.
Arms:
Platelet-rich plasma (PRP)
Intra-articular injection of autologous microfat and platelet-rich plasma
A preparation of autologous platelet-rich plasma (5mL) and autologous microfat (5mL) will be injected intra-articularly.
Arms:
Microfat autologous-Platelet-rich plasma (MG-PRP)
Size
180
Primary endpoint
KOOS score at 6 months
6 months
Eligibility criteria
Inclusion Criteria:
* Patients of both gender, between 20 and 75 year-old.
* Symptomatics degenerativ or post traumatic chondropathy, on at least one of the 3 knee compartments ICRS grade 2, 3 or 4 with VAS\>4 and failure of well-conducted medical treatment for at least 1 year (palliative analgesics adapted to the pain, AINS, rehabilitation by a physiotherapist, injections intra-articulaires de corticoïdes et/ou d'acide hyaluronique)
* Varus or valgus less than or equal to 5°.
* BMI greater than 20 (in order to have sufficient fatty tissue)
* Informed consent signed by the patient
* HB \> 10g/dl
* Negative beta-HCG at inclusion and effective contraception for patients of childbearing age, for 1 month.
* Beneficiaries of or affiliated to a social security system
Exclusion Criteria:
* Contraindications to MRI : ocular foreign bodies, pacemaker, neurostimulator, cochlear implant, vascular clips, metallic heart valve
* Body mass index (BMI) of less than 20 kg/m2 not allowig to obtain a sufficient quantity of adipose tissue.
* Thrombocytopenia \< 150 G/L
* Thrombocytosis \> 450 G/L
* Known thrombopathy
* TP=\> PR \< 70%.
* TCA=\> APR \> 1.20s
* Anemia HB \< 10g/dl
* Positive markers for the following active infectious diseases: HIV 1 and HIV 2 human immunodeficiency virus infection; HTLV I and II virus infection; Hepatitis B virus infection; Hepatitis C virus infection; Syphilis causative agent infection.
* Use of antiplatelet agents, aspirin, anti-vitamin K drugs for less than 15 days.
* Chronic treatment with oral corticosteroids or the use of such treatment less than 2 weeks prior to inclusion
* Intra-articular corticosteroid injection less than 2 months prior to inclusion
* Intra-articular injection of hyaluronic acid less than 2 months prior to inclusion
* Non-steroidal anti-inflammatory drugs less than 15 days prior to inclusion
* Recent fever or infection (bacterial or viral) less than one month old
* Autoimmune diseases
* Inflammatory arthritis
* Immune deficiency
* Ongoing or chronic infectious diseases (viral or bacterial)
* T Malignant tumours or history of malignant tumours less than 5 years prior to inclusion
* Pregnant or lactating women
* Adults protected by law (guardianship or curatorship)
* Patient participating simultaneously in another research project involving the human person
* Minors
* Persons residing in a health or social institution
* Persons in emergency situations
* Persons deprived of liberty
* Persons not covered by the French social security scheme
* Contraindication to local anesthesia and/or surgery
* Allergy to local anesthetics
* Inmates
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 180, 'type': 'ESTIMATED'}}
Updated at
2023-10-27
1 organization
3 products
1 indication
Organization
Assistance Publique Hopitaux De MarseilleIndication
Osteoarthritis of the Knee