The Effect of Delta-8-THC vs Delta-9-THC on Simulated Driving Performance and Measures of Impairment

IRB00394164

Delta-8-THC is an isomer of delta-9-THC that has become widely available due to the legalization of hemp and its derivatives. Very little controlled research has been conducted with delta-8-THC and some research suggests it produces similar effects to delta-9-THC, albeit at lower potency. The present study will evaluate the dose effects of delta-8-THC, compared with delta-9-THC, on simulated driving performance, field sobriety tests, cognitive performance, and biomarkers of exposure to cannabinoids. The results will inform policy and education related to impairment due to acute delta-8-THC exposure via vaporization and oral ingestion.

2024-07-01

2025-12-01

2025-12-01

Not yet recruiting

Early phase I

45

Inclusion Criteria: 1. Be between the ages of 18 and 55 2. Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests 3. Test negative for recent cannabis use prior to each experimental test session 4. Test negative for drugs of abuse and alcohol prior to each experimental test session 5. Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at clinic admission 6. Have a body mass index (BMI) in the range of 19 to 36 kg/m2 7. Report use of cannabis in the past 3 years (both sub-studies) and prior experience inhaling cannabis (either via smoking or vaporization) for vaporization sub-study participation 8. Have not donated blood in the prior 30 days. 9. Have a current government-issued driver's license Exclusion Criteria: 1. Non-medical use of psychoactive drugs other than nicotine, alcohol, or caffeine in the month prior to study participation. 2. History of or current evidence of health issues judged by the investigator to put the participant at greater risk of experiencing an adverse event due to drug exposure or completion of other study procedures. 3. Current concomitant medication use that may interact with the study drug (∆8-THC and ∆9-THC). 4. History of xerostomia (dry mouth), or the presence of mucositis, gum infection or bleeding, or other significant oral cavity disease or disorder that in the investigator's opinion may affect the collection of oral fluid samples. 5. Participation in other research projects that could impact the present study

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2024-05-20