Clinical trial
A Single-Arm, Open-Label Pilot Trial of the Safety and Immunogenicity of a Quadrivalent Human Papillomavirus Vaccine in HIV-1-Infected Men
Name
AMC-052
Description
RATIONALE: Vaccines made from human papillomavirus may help the body build an effective immune response to kill HIV cells.
PURPOSE: This phase II trial is studying the side effects and how well human papillomavirus vaccine therapy works in treating men with HIV-1 infection.
Trial arms
Trial start
2007-11-01
Estimated PCD
2010-05-01
Trial end
2011-10-01
Status
Completed
Phase
Early phase I
Treatment
Gardasil
week 0, 8, 24, 128
Arms:
Gardasil
Other names:
quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine
Size
112
Primary endpoint
Occurrence of ≥ Grade 3 Adverse Events Probably or Definitely Related to the Vaccine
All study visits
Detectable Human Papillomavirus (HPV) Antibody to Type 6 a Month After the Completion of HPV Vaccination Series (Week 28) Among Patients Seronegative for Type 6 at Baseline
Week 28
Detectable Human Papillomavirus (HPV) Antibody to Type 11 a Month After the Completion of HPV Vaccination Series (Week 28) Among Patients Seronegative for Type 11 at Baseline
Week 28
Detectable Human Papillomavirus (HPV) Antibody to Type 16 a Month After the Completion of HPV Vaccination Series (Week 28) Among Patients Seronegative for Type 16 at Baseline
Week 28
Detectable Human Papillomavirus (HPV) Antibody to Type 18 a Month After the Completion of HPV Vaccination Series (Week 28) Among Patients Seronegative for Type 18 at Baseline
Week 28
Eligibility criteria
DISEASE CHARACTERISTICS:
Inclusion criteria:
* HIV-1 infection, as documented by any licensed ELISA test kit and confirmed by western blot prior to study entry
* HIV-1 culture, HIV-1 antigen, plasma HIV-1 RNA, or a second antibody test by a method other than ELISA is acceptable as an alternative confirmatory test
* Anal human papilloma virus DNA PCR-negative for either type 16 and/or type 18 within 90 days prior to entry
* If receiving antiretroviral therapy:
* Receipt of antiretroviral therapy for at least 6 months prior to entry
* No change in antiretroviral therapy within 30 days prior to entry
* CD4 cell count \> 200 cells/mm³ within 90 days prior to study entry
* HIV-1 RNA \< 200 copies/mL within 90 days prior to entry
* If not receiving antiretroviral therapy:
* CD4 cell count ≥ 350 cells/mm³ within 90 days prior to study entry
* No plans to start antiretroviral therapy prior to week 28
* Normal anal cytological result, or atypical squamous cell of undetermined significance or low-grade squamous intraepithelial lesions (SIL) result within 90 days prior to entry
Exclusion criteria:
* Current or history of anal or perianal carcinoma
* Anal cytological result of high-grade SIL (HSIL), atypical squamous cells suggestive of HSIL, or suggestive of invasive carcinoma at screening or a history of these results
* Presence of high-grade anal intraepithelial neoplasm (HGAIN) (e.g., AIN 2 or 3, or perianal intraepithelial neoplasia grade 2 or 3), or invasive carcinoma at pre-entry, or history of HGAIN
* Current or history of anal or peri-anal condyloma is allowed
PATIENT CHARACTERISTICS:
Inclusion criteria:
* Karnofsky performance status 70-100%
* Absolute neutrophil count \> 750 cells/mm³
* Hemoglobin ≥ 9.0 g/dL
* Platelet count ≥ 100,000/mm³
* Creatinine clearance ≥ 60 mL/min
* AST and ALT ≤ 3 times ULN
* Total or conjugated (direct) bilirubin ≤ 2.5 times ULN
Exclusion criteria:
* Serious medical or psychiatric illness, active drug or alcohol use, or dependence that, in the opinion of the site Investigator, would interfere with adherence to study requirements
* Serious illness requiring systemic treatment and/or hospitalization within the past 45 days
* Allergy to yeast or any of the components of quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine
* Hemophilia
PRIOR CONCURRENT THERAPY:
Inclusion criteria:
* See Disease Characteristics
Exclusion criteria:
* Prior splenectomy
* Currently receiving anticoagulation therapy other than acetylsalicylic acid
* Use of any systemic antineoplastic or immunomodulatory treatment, systemic corticosteroids, investigational vaccines, interleukins, interferons, growth factors, or IVIG within 45 days prior to study entry
* Routine standard of care, including hepatitis A or B, influenza, or pneumococcal and tetanus vaccines are not excluded
* Hepatitis C co-infected patients are eligible provided no concurrent initiation of treatment for hepatitis C
* Prior receipt of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine or other HPV vaccine
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 112, 'type': 'ACTUAL'}}
Updated at
2023-11-14
1 organization
1 product
2 indications
Organization
AIDS Malignancy ConsortiumProduct
GardasilIndication
InfectionIndication
Precancerous Condition