Exploring the Mechanisms Underlying the Analgesic Properties of Cannabidiol Using Magnetic Resonance Spectroscopy

IRB_00124865

This is a study designed to examine the neurochemical mechanisms associated with Cannabidiol (CBD) versus placebo for chronic non-cancer pain.

2020-03-16

2024-12-30

2025-02-28

Recruiting

Early phase I

52

Inclusion Criteria: * Age between 18-50 yrs. * Chronic musculoskeletal and joint pain for at least 3 months or longer. * Participants must live within a 60 mile radius of Salt Lake City, Utah to be eligible. Exclusion Criteria: * Current or past neurological illness. * Substance abuse or dependence within the prior 90 days. * Contraindication to brain MRI. * Type I and type II diabetes. * Unstable medical conditions. * Consumption of more than 2 drinks of alcohol per night. * Current pregnancy or planning to become pregnant or breastfeeding. * History of seizures or head trauma at PI discretion. * Active or history of major mental illness * Use of opioid medications in the past 30 days. * LFT results 3 times greater than the upper limit of normal at the screening. * Participants may be excluded if the PI feels they do not meet safety criteria.

{'studyType': 'INTERVENTIONAL', 'phases': ['EARLY_PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'CROSSOVER', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 52, 'type': 'ESTIMATED'}}

2024-04-26