Post Operative Atril Fibrillation : The Impact of Oral Vitamin C in Reducing the Risk in Egyptian CABG Patients

Vitamin C in POAF prevention

Post operative atrial fibrillation (POAF) is one of the most common complications that takes place worldwide after coronary artery bypass surgeries (CABG). Many studies suggest using vitamin C as an additional treatment alongside standard therapies, such as statins and β-blockers, to reduce the risk of postoperative atrial fibrillation (POAF) in patients undergoing (CABG). Supplemental therapy with vitamin C may provide a more robust preventive effect against POAF compared to using statins and β-blockers due to its strong antioxidant effect. This implies that vitamin C can enhance the effectiveness of those medications used for POAF prevention by decreasing oxidative stress induced by the surgery. There are conflicting data on whether or not vitamin C as an antioxidant has a protective effect against postoperative atrial fibrillation and has a significant role in shortening length of ICU and hospital stay . Even in those studies that show positive relationship of vitamin C in AF prevention, there is a diversity in the dosing regimen of vitamin C used among those previous studies. To the best of our knowledge, most researches were conducted predominantly within a single geographic region, such as Iran, this raises the concerns about the potential bias and limits our ability to apply the findings to a broader global population. Here, the investigators aimed to evaluate the effectiveness of vitamin C supplementation and to figure out which dose of vitamin C will prevent post-operative AF and decrease complications such as hospital stay, pneumonia and surgical site infection among older Egyptian adults.

2020-10-13

2023-10-15

2023-10-30

Active (not recruiting)

Early phase I

180

Inclusion criteria: * Patients who underwent elective isolated on-pump coronary artery bypass surgery * Age: 50 to 70 years * No history of Coronary artery by pass surgery * Taking maximum tolerated beta-blocker before and after surgery * Normal left atrium and left ventricle dimensions Exclusion Criteria: * preoperative history of Atrial fibrilliation * permanent pacemaker or significant bradycardia * Hyperoxaluria or history of nephrolithiasis * Left ventricular ejection fraction \< 40% * Contraindications to beta-blocker or vitamin C. * Patients with history of vitamin C consumption before surgery. * Chronic kidney disease with creatinine \>2 mg/dl.

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2023-10-10