Clinical trial
A Study of the Pharmacokinetics of [14C]-DNL343 Following a Single Oral Dose in Healthy Male Participants
Name
DNLI-F-0009
Description
This is a Phase 1, open-label, nonrandomized, single-dose study in healthy male participants to investigate the absorption, metabolism and excretion of DNL343.
Trial arms
Trial start
2024-03-01
Estimated PCD
2024-05-01
Trial end
2024-05-01
Status
Recruiting
Phase
Early phase I
Treatment
[14C]-DNL343
Single dose
Arms:
14C-DNL343
Size
7
Primary endpoint
PK Parameter: AUC0-∞
28 days
PK Parameter: AUC0-tlast
28 days
PK Parameter: Cmax
28 days
PK Parameter: Tmax
28 days
PK Parameter: t1/2
28 days
Total radioactivity in plasma and whole blood
28 days
Total radioactivity in blood-to-plasma ratio
28 days
Extent and rate of recovery of total radioactivity in urine and feces
28 days
Eligibility criteria
Inclusion Criteria:
* Males, aged between 18 to 65 years, inclusive
* Body mass index between 18.0 and 32.0 kg/m2
* In good health
* When engaging in sex with a woman of child bearing potential, both the male participant and his female partner must use highly effective contraception
* History of a minimum of 1 bowel movement per day
Exclusion Criteria:
* History or clinical manifestation of any clinically significant metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder
* Have a history of malignancy, except fully resected basal cell carcinoma
* History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance
* History of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs
* Have previously completed or withdrawn from this study or any other study investigating DNL343 and have previously received DNL343
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 7, 'type': 'ESTIMATED'}}
Updated at
2024-03-01
1 organization
1 product
1 indication
Indication
Healthy Control ParticipantsOrganization
Denali TherapeuticsProduct
[14C]-DNL343