Clinical trial
Boosting Immune Response With Copanlisib in Locally Advanced Unresectable Non-Small Cell Lung Cancer Receiving Durvalumab, A Phase Ib Study
Name
MCC-20-LUN-119-PMC
Description
The current study focuses on unresectable stage III non-small cell lung cancer (NSCLC) patients who are starting Durvalumab consolidation after concurrent chemoradiation with a goal of cure. The overall hypothesis of this study is that the addition of Copanlisib to Durvalumab will be well-tolerated at a biweekly schedule. It will test whether the addition of Copanlisib to Durvalumab can overcome resistance to Durvalumab.
Trial arms
Trial start
2021-05-12
Estimated PCD
2025-06-01
Trial end
2025-06-01
Status
Active (not recruiting)
Phase
Early phase I
Treatment
Durvalumab
Durvalumab will be delivered at 10mg/kg via IV infusion at days 1 and 15 every 28 days or 1500 mg on D1, q4w.
Arms:
Copanlisib (30-60mg iv)
Other names:
Imfinzi
Copanlisib
Copanlisib will be delivered at various doses (30-60mg/kg) via IV infusion at days 1 and 15 every 28 days.
Arms:
Copanlisib (30-60mg iv)
Other names:
Aliqopa
Size
11
Primary endpoint
Dose Limiting Toxicity
28 days
Eligibility criteria
Inclusion Criteria:
* Histologically confirmed NSCLC (e.g., adenocarcinoma, squamous cell) deemed unresectable or inoperable who have received concurrent chemoradiation.
* Durvalumab will be started as consolidation therapy
* Have at least one measurable lesion.
* ECOG performance status ≤2.
* Adequate organ and marrow function.
* Ability to understand and the willingness to sign a written informed consent document.
Exclusion Criteria:
* Mixed Non-small cell and small cell histology; known EGFR and/or ALK driver mutations.
* Treated with sequential chemoradiation therapy.
* Autoimmune disease, such as rheumatoid arthritis, systemic lupus erythematosus, requiring systemic treatment with immunosuppressant in the past two years.
* Patients who are receiving any other investigational agents orally or intravenously.
* Systemic steroid for other purpose exceeding 10 mg prednisone a day except local injection at the discretion of the investigator.
* Solid organ or bone marrow transplant recipients.
* History or concurrent condition of interstitial lung disease of any severity and/or severely impaired lung function.
* Patients with uncontrolled inter-current illness.
* Patients with psychiatric illness/social situations that would limit compliance with study requirements and patients with seizure disorder not well controlled.
* Received live vaccine in the past 4 weeks.
* Pregnant or breast-feeding/lactating women.
* Receiving medications prohibited by the study.
* New York Heart Association Class 3 or above.
* Myocardial infarction within the last 6 months.
* Unstable angina.
* Venous thromboembolism within last 3 months.
* Evidence or history of bleeding diathesis. Any hemorrhage or bleeding event ≥ CTCAE Grade 3 within 4 weeks.
* Proteinuria of ≥ CTCAE Grade 3 or estimated by urine protein: creatinine ratio \> 3.5
* Major surgeries within the last 28 days.
* Any illness or medical conditions that are unstable or could jeopardize the safety of patients and their compliance in the study.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'interventionModelDescription': 'Dose finding cohort and dose expansion cohort up to 18 patients', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 11, 'type': 'ACTUAL'}}
Updated at
2024-02-13
1 organization
1 product
1 drug
1 indication
Organization
Zhonglin HaoDrug
AN0025Indication
Lung CancerProduct
Copanlisib