Influence of Glycaemic Variability on Oxidative Stress and High-density Lipoprotein (HDL) Function in Type-1 Diabetes

Duvillard Hors AOI 2011

As glycaemic variability on the one hand and hypoglycaemia on the other are associated with oxidative stress and inflammation, they are likely, in type-1 diabetic patients, to affect the oxidation of lipoproteins and HDL function, by altering their anti-atherogenic properties. The aim of this study is thus to determine, in patients with Type 1 Diabetic (T1D) who will wear a glycaemic Holter for 1 week, the glycaemia parameters (mean glycaemia, duration of hypoglycaemia, duration of hyperglycaemia, mean amplitude of glycaemic excursions) associated with proatherogenic alterations in lipoproteins, in particular: * LDL oxidation * HDL oxidation and alterations of HDL function (anti-inflammatory capacity, antioxidant capacity)

2012-05-29

2018-04-17

2018-04-17

Completed

60

Inclusion Criteria: * Patients who have provided written consent * Patients with national health insurance cover Patients with T1D * T1D Patients treated with insulin via a pump or multiple injections * HbA1c \< 9.5 % Control patients * Normal fasting glycaemia (\< 6.1 mmol/L) * Age \> 18 years, matched for sex and age with T1D patients All patients * Normal serum HDL cholesterol (\> 1.04 mmol/L in men, \> 1.30 mmol:L in women) * Serum LDL cholesterol \< 5 mmol/L * triglyceridemia \< 1.7 mmol/L * Waist circumference \< 102 cm in men, \< 88 cm in women Exclusion Criteria: * Smoking * Kidney failure (Creatinine clearance\< 60 ml/min/1.73 m2) * Liver failure * Dysthyroidism * Medication that interferes with lipoprotein metabolism (lipid-lowering agents, oestroprogestative, anti-HIV, corticoids, retinoic acid), unless stopped for at least one 1 month * Antioxidant (vitamin E, dietary supplements, DHA) * Pregnancy of more than 15d

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'NON_RANDOMIZED', 'interventionModel': 'PARALLEL', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 60, 'type': 'ACTUAL'}}

2024-02-21