Clinical trial

Analgesic Efficacy of Adding Dexmedetomidine VS Magnesium Sulphate as Adjuvants With Bupivacaine in Ultrasound-guided Erector Spinae Plane Block for Post Thoracotomy Pain

Name
N-80-2022/NSC
Description
Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy including Intercostal nerve block, Erectospinae plane block and serratus block. Multiple adjuvants have been used in regional analgesia including adrenaline,clonidine,magnesium sulphate,dexmedatomidine and opoids.
Trial arms
Trial start
2023-05-15
Estimated PCD
2024-03-25
Trial end
2024-04-27
Status
Recruiting
Treatment
Bupivacaine
Bupivacaine 0.25%
Arms:
Erector spinae plane block with 0.25% bupivacaine
Bupivacaine + Magnesium
Bupivacaine 0.25% + Magnesium
Arms:
Erector spinae plane block with 0.25% bupivacaine and Magnesium
Bupivacaine + Dexmedetomidine
Bupivacaine 0.25% + Dexmedetomidine
Arms:
Erector spinae plane block with 0.25% bupivacaine and Dexmedetomidine
Size
60
Primary endpoint
Total postoperative morphine consumption
First 24 hours postoperatively
Eligibility criteria
Inclusion Criteria: * Age from 18 to 65 years. * Male and female sexes. * ASA I-II.,III * Cancer patients undergoing thoracotomy incisions * Body mass index (BMI) from 18.5 to 30 kg/m2 Exclusion Criteria: * Patient refusal * Known allergy to any of the used drugs * Low platelet count, any coagulation defect
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'maskingDescription': 'Double blinded', 'whoMasked': ['CARE_PROVIDER', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 60, 'type': 'ESTIMATED'}}
Updated at
2024-02-20

1 organization

3 products

1 indication

Indication
Analgesic